文章摘要
苟发香,张晓曙,姚进喜,于德山,魏孔福,张宏,杨筱婷,杨建军,刘海霞,成瑶,蒋小娟,郑芸鹤,吴斌,刘新凤,李慧.甘肃省新型冠状病毒肺炎流行病学特征分析[J].中华流行病学杂志,,():
甘肃省新型冠状病毒肺炎流行病学特征分析
Epidemiological characteristics of COVID-19 in Gansu province
收稿日期:2020-02-29  出版日期:2020-04-01
DOI:10.3760/cma.j.cn112338-20200229-00216
中文关键词: 新型冠状病毒肺炎;流行病学特征
英文关键词: COVID-19;Epidemiological characteristic
基金项目:国家科技重大专项(2017ZX10103006)
作者单位E-mail
苟发香 甘肃省疾病预防控制中心, 兰州 730000  
张晓曙 甘肃省疾病预防控制中心, 兰州 730000  
姚进喜 甘肃省疾病预防控制中心, 兰州 730000  
于德山 甘肃省疾病预防控制中心, 兰州 730000  
魏孔福 甘肃省疾病预防控制中心, 兰州 730000  
张宏 甘肃省疾病预防控制中心, 兰州 730000  
杨筱婷 甘肃省疾病预防控制中心, 兰州 730000  
杨建军 甘肃省疾病预防控制中心, 兰州 730000  
刘海霞 甘肃省疾病预防控制中心, 兰州 730000  
成瑶 甘肃省疾病预防控制中心, 兰州 730000  
蒋小娟 甘肃省疾病预防控制中心, 兰州 730000  
郑芸鹤 甘肃省疾病预防控制中心, 兰州 730000  
吴斌 甘肃省疾病预防控制中心, 兰州 730000  
刘新凤 甘肃省疾病预防控制中心, 兰州 730000 liuxf606@126.com 
李慧 甘肃省疾病预防控制中心, 兰州 730000  
摘要点击次数: 1291
全文下载次数: 883
中文摘要:
      目的 对甘肃省确诊的新型冠状病毒肺炎(COVID-19)病例进行流行病学特征分析,探索疫情流行的阶段性特征和变化。方法 通过流行病学调查收集甘肃省COVID-19病例资料,包括基本资料、流行病学史、发病、就诊和确诊时间、临床表现等信息。结果 截至2020年2月25日,甘肃省共报告91例确诊病例,COVID-19流行分为输入病例期、输入病例与本地病例并存期、本地病例为主期3个阶段。聚集性疫情病例共63例(69.23%)。医务人员有3例,均为非职业暴露感染。首发症状为发热、咳嗽和乏力的比例分别为54.95%(50/91)、52.75%(48/91)和28.57%(26/91),且在3个阶段中的比例呈下降趋势,但只有发热与乏力症状的差异有统计学意义(趋势χ2值分别为2.20和3.18,P<0.05);3个阶段的重型/危重型病例比例分别为42.86%(6/14)、23.73%(14/59)和16.67%(3/18),呈下降趋势(H=6.40,P<0.05);潜伏期随着疫情的3个阶段有延长的趋势(F=51.65,P<0.01);发病到就诊、发病到确诊的时间间隔随着疫情进展有缩短的趋势(F值分别为5.32和5.25,P<0.01);基本再生数(R0)从输入病例期的2.61降至本地病例为主期的0.66。结论 甘肃省COVID-19流行早期均为湖北省输入,聚集性疫情占三分之二,未发现医务人员职业性暴露感染。总体流行呈阶段性变化特征,随着疫情进展有首发症状不明显和潜伏期延长的特点,并提示体温监测不能作为单一的早期筛查手段。
英文摘要:
      Objective To understand the epidemiological characteristics of COVID-19 cases in different epidemic stages in Gansu province. Methods Epidemiological investigation was conducted to collect the information of confirmed COVID-19 cases, including demographic, epidemiological and clinical information. Results As of 25 February 2020, a total of 91 confirmed COVID-19 cases had been reported in Gansu. The epidemic of COVID-19 in Gansu can be divided as three different stages, i.e. imported case stage, imported-case plus indigenous case stage, and indigenous case stage. A total of 63 cases were clustered cases (69.23%), 3 cases were medical staff infected with non-occupational exposure. The initial symptoms included fever (54.95%, 50/91), cough (52.75%, 48/91), or fatigue (28.57%, 26/91), the proportion of each symptom showed a decreasing trend along with the three epidemic stages, but only the differences in proportions of fever (trend χ2=2.20, P<0.05) and fatigue (trend χ2=3.18, P<0.05) among the three epidemic stages were statistically significant. The cases with critical severe symptoms accounted for 42.85% (6/14), 23.73% (14/59) and 16.67% (3/18), respectively, in three epidemic stages, showed a decreasing trend (H=6.45, P<0.05). Also, the incubation period prolonged along with the epidemic stage (F=51.65, P<0.01), but the intervals between disease onset and hospital visit (F=5.32, P<0.01), disease onset and diagnosis (F=5.25, P<0.01) became shorter along with the epidemic stage. Additionally, the basic reproduction number (R0) had decreased from 2.61 in imported case stage to 0.66 in indigenous case stage. Conclusions The COVID-19 epidemic in Gansu was caused by the imported cases, and about 2/3 cases were clustered ones. No medical worker was observed to be infected by occupational exposure. With the progression of COVID-19 epidemic in Gansu, the change in initial symptom and incubation period suggests, the early screening cannot only depend on body temperature monitoring.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭