文章摘要
何纳,陆一涵,李立明,沈洪兵,杨维中,冯子健,国家自然科学基金新冠应急专项课题协作组.新型冠状病毒无症状感染的流行病学研究设计[J].中华流行病学杂志,,():
新型冠状病毒无症状感染的流行病学研究设计
Epidemiological study design of asymptomatic infection of the 2019 novel coronavirus
收稿日期:2020-07-23  出版日期:2020-07-31
DOI:10.3760/cma.j.cn112338-20200723-00975
中文关键词: 新型冠状病毒;新型冠状病毒肺炎;无症状感染;血清流行病学
英文关键词: 2019 novel coronavirus;COVID-19;Asymptomatic infection;Sero-epidemiological study
基金项目:基金项目国家自然科学基金新冠应急专项(82041026,82041027,82041028,82041029,82041030,82041031,82041032,82041033)
作者单位E-mail
何纳 复旦大学公共卫生学院, 上海 200032  
陆一涵 复旦大学公共卫生学院, 上海 200032  
李立明 北京大学公共卫生学院, 100191 lmleeph@vip.163.com 
沈洪兵 南京医科大学公共卫生学院, 211166 hbshen@njmu.edu.cn 
杨维中 中国医学科学院, 北京 100730 yangwz@chinacdc.cn 
冯子健 中国疾病预防控制中心, 北京 102206 fengzj@chinacdc.cn 
国家自然科学基金新冠应急专项课题协作组   
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中文摘要:
      新型冠状病毒可引起新型冠状病毒肺炎(COVID-19)。患者是主要传染源,但无症状感染者也可能成为传染源,且引起社区传播的风险更大。目前,关于人群中无症状感染率及其传染性尚无定论。本研究设计选取COVID-19疫情高发与低发地区作为研究现场,对社区人群和重点人群(包括COVID-19治愈病例、确诊病例的密切接触者、医护人员/CDC流行病学调查人员、发热门诊患者)开展流行病学问卷调查、血清抗体和核酸检测,确定不同人口社会学特征和暴露风险人群的新型冠状病毒无症状感染率,及其流行病学特征;对确诊病例和无症状感染者开展流行病学随访,分析血清抗体水平变化,评估传染性和传播风险。
英文摘要:
      COVID-19 is caused by the 2019 novel coronavirus (2019-nCoV). COVID-19clinical cases are considered as the principal source of infection, however, asymptomatic cases may also play a role in the transmission. Significant gap exists in terms of the proportion or prevalence and transmissibility of asymptomatic cases. This study design plans to use data from areas with different epidemiological profiles to investigate the COVID-19 epidemic in China. In each selected region, both general community residents and key populations at high risk of COVID-19 infection, including recovered COVID-19 cases, close contacts of confirmed COVID-19 cases, medical professionals, investigators at CDCs, and visitors to fever clinics, will be recruited and examined for viral RNA of 2019-nCoV and serum antibodies. Prevalence and characterization of asymptomatic cases will be determined, stratified by varied demographics and exposure risk. During the follow-up, the change in the serum antibodies will be studied prospectively in the symptomatic and asymptomatic cases to address the scientific and public health concerns of infectivity and transmissibility of 2019-nCoV.
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