文章摘要
高明,陈怀春,于晓涛,纪树立.免疫血清对鼠疫杆菌的杀伤作用[J].中华流行病学杂志,1986,7(3):149-152
免疫血清对鼠疫杆菌的杀伤作用
Bactericidal Activity of Immune Serum against Y.pestis
收稿日期:  出版日期:2021-05-27
DOI:
中文关键词: 
英文关键词: 
基金项目:
作者单位
高明 中国预防医学科学院流行病学微生物学研究所 
陈怀春 内蒙哲盟地方病防治站 
于晓涛 青海地方病防治研究所 
纪树立 中国预防医学科学院流行病学微生物学研究所 
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中文摘要:
      1.豚鼠和家兔免疫血清对28℃生长的鼠疫杆菌株EV、559均有杀伤活性。该活性见于细菌和血清37℃作用一段时间后。
2.鼠疫杆菌的不同株(EV、559)对免疫血清杀伤敏感性及杀伤动态表现不同。前者的杀伤在接触早期就开始。后者在进入对数生长期后才开始。
4.免疫血清杀菌能力初步认为与保护力相关
。5.免疫豚鼠间接血凝(PHA)试验阴性并不能绝对认为是缺乏抗鼠疫免疫力。
英文摘要:
      The bacterial viability of Y.pestis in animal the immune serum was studied by means of guinea pig and rabbit serum bacteriocidal assay. When Y.pestis EV and 559 (virulent) were exposed to these sera at 37℃, we found that strain EV was the first to succumb at the heginning while strain 559 reduced its clone forming only during the logarithmic phase. We demonstrated too the correlation between this serum activity and guinea pig protection but foiled in show any relationship between the titre of passive haemoagglutination and the serum activity. It is suggested that the serum bactericidal test may be a useful tool in estimating the animal protection potency.
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