| 肖黔林,周忠海,李秋丽,巩志业,谢全美,张世达,王瑞华,杨昌伦,刘大西,汪凯,柯应龙,李观聪,王枢群.质粒分析、噬菌体定型及耐药谱测定在伤寒流行病学调查中的应用[J].中华流行病学杂志,1987,8(5):272-275 |
| 质粒分析、噬菌体定型及耐药谱测定在伤寒流行病学调查中的应用 |
| A Comparison Study on the Application of Plasmid Profile Analysis, Phagetyping and Antimicrobial Susceptibility Testing to the Epidemiological Investigation of Typhosaid |
| 收稿日期: 出版日期:2021-05-29 |
| DOI： |
| 中文关键词: 质粒分析 噬菌体定型 耐药谱测定 伤寒沙门氏菌 |
| 英文关键词: Plasmid profile analysis-Phagetyping Antimicrobial susceptibility pattern Salmonella typhoid |
| 基金项目: |
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| 中文摘要: |
| 用质粒分析、噬菌体定型、耐药谱测定这三种方法检查了贵州省安顺地区一九八五年十月伤寒爆发流行期和一九八六年春夏季分离的伤寒沙门氏菌。结合流行病学分析,看出质粒分析及噬菌体定型是检定流行菌株特点的有用方法,尤其质粒分析,在同流行病学资料的符合性,操作方法简易方面优于噬菌体定型,而耐药谱的应用则有很大的局限性。通过质粒分析及噬菌体定型,明确看出一九八五年爆发流行主要是由携带100Md质粒的菌株或噬菌体定型为M1型的伤寒沙门氏菌所引起。一九八六年的病例仍然是这种菌株在起主导作用。同时也指出,该地区仍有个别病例属其它细菌克隆所致。 |
| 英文摘要: |
Plasmid Profile analysis, phagetyping and antimicrobial susceptibility Pattern have been used to analyse the strains of S. typhoid isolated during the epidemic happened in October, 1985 and in the period of spring-summer, 1986 in An Shun Prefecture of Guizhou Province. In combination with epidemiological analysis, it was shown that plasmid profile analysis and phagetyping Proved useful methods in detecting the characteristics of prevailing strains. In terms of finding the coincidence with the epidemiological data and easiness of performance, plasmid profile as found better than phagetyping. But the antimicrobiol susceptibility pattern gave an unsatisfactory result.
According to the result of plasmid profile analysis, it was clearly seen that the strain clone witn 100Md plasmid was the main causative agent for the epidemic. And strains with phagetypen M1 were found the principal pathogens for the epidemic on the basis of phagetyping. The same strains still caused sporadic typhoid in 1986. But it was also found that there were some other strain clones causing isolated cases. |
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