文章摘要
那英剑,胡孟璇.鼻咽癌病因学的病例—对照研究[J].中华流行病学杂志,1988,9(4):224-226
鼻咽癌病因学的病例—对照研究
Case-Control Study on Nasopharyngeal Carcinoma
收稿日期:  出版日期:2021-05-31
DOI:
中文关键词: 鼻咽癌  病例—对照研究  多因素分析
英文关键词: Nasopharyngeal carcinoma  Case-control study  Logistic regression
基金项目:
作者单位
那英剑 中山医科大学卫生统计教研室 
胡孟璇 中山医科大学卫生统计教研室 
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中文摘要:
      本文以病例—对照的方法探讨了在黑龙江省与鼻咽癌发生有关的危险因素。调查鼻咽癌病例及对照共127对。在单因素与条件Logistic回归分析中均表明幼儿期食咸鱼(OR=5.5, χ2=4.92, P<0.05)及长期生活在烧煤的环境中(OR=1.894, χ2=4.655, P<0.05)可能与鼻咽癌的发生有关。此外,条件Logistic回归分析还发现,鼻窦炎病史也可能与鼻咽癌的发生有联系(B=1.385, exp(B)=3,995, P<0.1)。在对病例及对照的一级亲属患恶性肿瘤情况的调查中发现,鼻咽癌病例组有肿瘤家族史者多于对照组,其差异有统计学意义(χ2=10.32, P<0.01)。
英文摘要:
      In order to study the risk factors associated with nasopharyngeal carcinoma(NPC) in Hei Longjiang province, a casecontrol study on nasopharyngeal carcinoma was conducted in the Affiliated Tumour Hospital of Harbin Medical University, Hei Longjiang province, from January to December of 1985. Interviews with 127 cases and 127 matched controls were made.
Classical matched-pair statistic analysis and Logistic regression analysis were made with IBM PC/XT microcomputer. Results from the classical analysis indicated that salted fish consumption during childhood was a risk factor for nasopharyngeal carcinoma (relative risk 5.5; P<0.05). Exposure to soot was also significantly associated with this disease (odds ratio 1.9; P<0.05). They were similar to those from Logistic regression analysis. Genetic factors may also play a very important role in the Pathogenesis of nasopharyngeal carcinoma. In Logistic regression analysis, we found that the nasosinusitis was also as a significant risk factor in the development of NPC (B=1.38; exp (B)=3.99).
There was no association between nasopharyngeal carcinoma and fried food, pickled vegetables, tobacco, or alcohol etc. The sexsual difference in etiologic constitution was not found in the study either.
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