文章摘要
苏万年,范瑛,王福平,陈海平,刘金莲,董春明,周金福,李湘生,谈忠良,宋华章,冷红英,刁连东,张义煌,张荣珍,迮文远.脊髓灰质炎疫苗免疫的研究 Ⅱ.不同剂型的脊髓灰质炎疫苗免疫应答的比较[J].中华流行病学杂志,1991,12(5):284-285
脊髓灰质炎疫苗免疫的研究 Ⅱ.不同剂型的脊髓灰质炎疫苗免疫应答的比较
A Study on Immunization of Polio Vaccine Ⅱ. Comparation of Responses Obtained by Different Forms of Polio Vaccine
收稿日期:  出版日期:2021-06-09
DOI:
中文关键词: 脊髓灰质炎疫苗  糖丸疫苗  液体疫苗
英文关键词: Polio vaccine  Polio dragee candy  Vaccine Polio liquid vaccine
基金项目:
作者单位
苏万年 卫生部北京生物制品研究所, 100024 
范瑛 江苏省卫生防疫站 
王福平 武进县卫生防疫站 
陈海平 卫生部北京生物制品研究所, 100024 
刘金莲 江苏省卫生防疫站 
董春明 卫生部北京生物制品研究所, 100024 
周金福 武进县卫生防疫站 
李湘生 武进县卫生防疫站 
谈忠良 武进县卫生防疫站 
宋华章 江苏省卫生防疫站 
冷红英 江苏省卫生防疫站 
刁连东 江苏省卫生防疫站 
张义煌 江苏省卫生防疫站 
张荣珍 中国预防医学科学院流行病学微生物学研究所 
迮文远 卫生部北京生物制品研究所, 100024 
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中文摘要:
      在江苏武进县农村对2~6月龄未服过脊髓灰质炎疫苗易感儿中,比较液体Ⅰ型,糖丸Ⅰ型和三价糖丸疫苗免疫应答。3种疫苗3次免疫后,抗体阳转率均达到95~100%,无统计学显著性差异,抗体几何平均滴度以液体Ⅰ型最高,液体Ⅰ型与糖丸Ⅰ型、Ⅰ型糖丸与三价糖丸无显著性差异,但三价糖丸与液体Ⅰ型相比有显著性差异。鉴于2~4月龄婴幼儿服用糖丸十分不便,且不易保证服苗效果,建议生产厂家克服困难创造条件尽快将脊灰糖丸剂型改为液体剂型。
英文摘要:
      A comparation study on the responses to the immunization of three different forms of polio vaccine, eg.Liquid I, Oral dragee candy I and Trivalent Oral dragee candy, on the susceptible children of 2~6 month of age was conducted in wujin County, Jiangsu Province The study showed no statistical difference between the responses to the three forms of the vaccine reaching 95~100%. For antibody GMT, Liquid I was the hightest, with little difference between Liquid I and Oral dragee candy I and Trivalent Oral dragee candy vaccine in statistics.But, there was a significant statistical difference between Trivalent Oral dragee candy and Liquid I. Considering that it is not easy to inoculate the children of 2~4 month of age with oral dragee candy vaccine, it is suggested all the producers try their best to convert the present oral dragee candy form into Liquid.
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