| 李新武,胡绪敬,高立慧,王君.B群脑膜炎奈瑟氏菌多位点酶电泳型及其流行病学意义[J].中华流行病学杂志,1992,13(3):129-133 |
| B群脑膜炎奈瑟氏菌多位点酶电泳型及其流行病学意义 |
| Multilocus Enzyme Electrophoretic Types of Neisseria meningitidis Serogroup B and Their Epidemiologic Significances |
| 收稿日期:1990-11-01 出版日期:2021-06-05 |
| DOI： |
| 中文关键词: B群脑膜炎奈瑟氏菌 多位点酶电泳型 克隆群体结构 |
| 英文关键词: Neisseria meningitidis serogroup B Multilocus enzyme electrophoretic types Clonal population structure |
| 基金项目:卫生部医学科学研究基金资助课题 |
|
| 摘要点击次数: 988 |
| 全文下载次数: 257 |
| 中文摘要: |
| 为了阐明自70年代以来在我国11个省和2个直辖市内从流脑病人和带菌者中所分离的B群脑膜炎奈瑟氏菌(Nm)之间的流行病学关系,采用多位点酶电泳技术研究了57株病人菌株和45株带菌者菌株的多位点酶电泳型和克隆群。初步发现,上述菌株可分为69个电泳型(ET)和13个克隆群。其中I克隆群最为重要,因为从70年代以来,它代表了63.7%的所试的全部菌株,并且代表了77.2%的病人菌株,它在地理地区分布上也相当广泛。另外,还有一个明显的趋向,即是从1984年以后,越来越多的病人菌株集中于I克隆群,而且优势ET也出现在I克隆群的复合ET1和ET24中。当同病人菌株相比较时,上述带菌者菌株显示了更复杂的不同的基因型,只有40%的菌株属于上述I克隆群和优势ET。 |
| 英文摘要: |
| In order to expound the epidemiologic relationshipes between the strains of Neisseria meningitidis serogroup B isolated from patients and carriers, 57 case and 45 carrier isolates were collected in 11 provinces and 2 municipalities of China since the 1970s and their multilocus enzyme electrophoretic types and clonal population structures were studied by multilocus enzyme electrophoresis. It was primarily found that the above strains could be divided into 69 electrophoretic types (ET) and 13 clones. Among others, the clone I was the most important one, because the clone I represented 63.7% of all strains tested and 77.2% of the case isolates and its district distributions were quite wide since the 1970s. In addition, it was an obvious tendency that more and more of the case isolates gathered up the clone I since 1984 and the predominant ETs also occured in the complex ET1 and ET24 of the clone I.As compared with the case isolates, the above carrier isolates displayed more heterogenetic types.Only 40% of all carrier isolates belonged to the above clone I and predominant ETs. |
|
查看全文
Html全文
查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
