| 张建营,金志宏,王春俭,王金太,杨翔飞,杨小昂,李东升,张亚冰,梅强,王凯娟,代丽萍,张金鉴,张梅喜,张瑞骞,张拴虎,吴颜领,崔效振,贾萍,张秀萍,彭红英,付朝红.河南省人群丁型肝炎病毒感染的血清流行病学调查研究[J].中华流行病学杂志,1995,16(6):365-368 |
| 河南省人群丁型肝炎病毒感染的血清流行病学调查研究 |
| A Seroepidemiological Study on Hepatitis D Virus (HDV) Infection in Henan Province, China |
| 收稿日期:1995-04-16 出版日期:2021-05-24 |
| DOI： |
| 中文关键词: 丁型肝炎病毒（HDV） 血清流行病学 |
| 英文关键词: Hepatitis D virus Seroepidemioloy |
| 基金项目:课题为河南省医药卫生科研重点资助项目 |
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| 摘要点击次数: 1240 |
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| 中文摘要: |
| 为了了解河南省丁型肝炎病毒(HDV)的人群感染情况,从1991~1993年对河南省十三个地区1 182例HBsAg阳性的各型乙肝病人及无症状HBsAg携带者血清标本进行HDAg、抗-HDV和三项标志检测。结果表明,河南省人群HDAg、抗-HDV、IgM-抗-HDV的总感染率分别为3.0%、3.5%、3.5%、8.1%。由此可见,河南地区确实存在有HDV感染,各地区感染率略有差别。从HDV感染率的年龄和性别分布来看,女性组(10.1%)略高于男性组(7.3%),60岁以上年龄组(21.4%)高于其它各年龄组。通过对各型乙肝病人血清标本中的HDV标志检测发现,携带者、急性乙肝、慢活肝、慢迁肝、肝硬化、重肝组病人HDV总感染率依次为8.7%、4.6%、7.7%、6.3%、11.9%、0.0.%,其中以肝硬化组病人HDV感染率最高。本研究结果证明HDV和HBV确实存在有重叠和重复感染,HDV的感染对HBV感染的慢性化和肝硬化的形成起一定的促进作用,在临床上应引起足够重视。 |
| 英文摘要: |
| In order to investigate the distribution of HDV infection in Henan province, a seroepidemiological study on HDV infection was conducted. A total number of 1182 HBsAg positive serum samples was collected from 13 prefectures and cities between 1991 and 1993. HDV markers (HDAg, anti-HDV, anti-HDV-IgM) were tested with Enzyme Linked Immunosorbant Assay (ELISA). The prevalence rates of HDAg,anti-HDV, anti-HDV-IgM and HDV infection rate were 3.0%, 3.5%, 3.5% and 8.1%, respectively. There were no statistically significant differences in the prevalence rates of HDV infection in patients of different sexes but significant differences in the prevalence rates of HDV infection in patients of different ages, especially in age group above 60, were noticed. We also noticed that the infection rates of HDV were 8.7%, 4.6%, 7.7%, 6.3%, 11.9% and 0.0% in the groups of HBsAg carriers, acute hepatitis, chronic active hepatitis, chronic persistent hepatitis, liver cirrhosis and severe hepatitis, respectively. These findings indicated that HDV infection was important in the pathogenesis of chronic hepatitis B and in the exacerbation from liver disease to cirrhosis. |
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