文章摘要
王志高,周伟忠,史鉴,王同来.伤寒Vi多糖菌苗流行病学效果观察[J].中华流行病学杂志,1997,18(1):26-29
伤寒Vi多糖菌苗流行病学效果观察
Efficacy and side Effects Following Immunization with Salmonella typhi Vi Capsular Polysaccharide Vaccine
收稿日期:1996-07-02  出版日期:2021-06-08
DOI:
中文关键词: 伤寒杆菌;伤寒Vi多糖菌苗
英文关键词: Salmonella typhi;Vi capsular polysaccharide vaccine
基金项目:
作者单位
王志高 江苏省卫生防疫站 南京 210009 
周伟忠 江苏省卫生防疫站 南京 210009 
史鉴 扬州市卫生防疫站 
王同来 宝应县卫生防疫 
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中文摘要:
      对我国研制的伤寒Vi多糖菌苗进行接种反应及流行病学效果观察,并以其稀释液作为对照,对777名接种者的反应观察结果表明,菌苗组发热弱、中反应率分别为16.93%和0.05%,对照组分别为15.01%和0.03%.两者发热反应率无显著差异。菌苗组仅出现2例局部轻反应。对81506名接种者观察,以血培养伤寒杆菌阳性作为病人诊断标准,菌苗的保护指数为3.49,保护率为71.35%。临床资料显示,接种组发病者的发热强度明显低于对照组发病者。作者认为该苗全身、局部反应轻微,安全性好,保护率较高,发病者可降低发热强度,且初免只需注射一针,是一种值得推广使用的新一代菌苗。
英文摘要:
      Efficacy and side effects following the immunization with Salmonella typhi Vi capsular polysaccharide vaccine (Vi) were assessed. The diluted solution (DS) of V was used as placebo. A total number of 777 children and adults were observed for side effect response. Mild and moderate fever appeared 16.93% and 0.05% in Vi group, 15.01% and 0.03% in DS group, respectively (statistically significant). Two cases with mild local reaction were observed in Vi group. A total number of 81506 vaccinees were investigated on the efficacy of Vi vaccine, using positive blood culture of Salmonolla typhi as a diagnostic criterion. The protective rate and index of vaccine were 71.35% and 3, 49% respectively.If 2 cases of positive Widal's test were included in, the protective rate would come up to 78.17% with a protective index 4.85. Clinical data showed that fever seen in the cases in Vi group was much lower than that of DS group. The systematic and local reaction of Vi vaccine were mild. The vaccine is safe and has high protective rate. It can also decrease the degree of fever with only one single dose as primary immunization. We believe Vi vaccine may serve as a vaccine of new generation to be promoted.
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