文章摘要
金银龙,王汉章,顾珩,程义斌.吸烟者淋巴细胞染色体畸变和微核形成的观察[J].中华流行病学杂志,1997,18(1):40-42
吸烟者淋巴细胞染色体畸变和微核形成的观察
Observation of Chromosome Aberration and Micronucleus Formation in Peripheral Blood Lymphocytes among Cigarette Smokers
收稿日期:1996-05-06  出版日期:2021-06-08
DOI:
中文关键词: 吸烟者;染色体
英文关键词: Smoker;Chromosome
基金项目:
作者单位
金银龙 中国预防医学科学院环境卫生与卫生工程研究所 北京 100050 
王汉章 中国预防医学科学院环境卫生与卫生工程研究所 北京 100050 
顾珩 中国预防医学科学院环境卫生与卫生工程研究所 北京 100050 
程义斌 中国预防医学科学院环境卫生与卫生工程研究所 北京 100050 
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中文摘要:
      采用染色体畸变和微核分析两个具有相关性的遗传物质损伤观察指标,同时观察了男性健康吸烟者遗传物质的损伤情况。结果表明,吸烟组超倍体细胞单、染色单体型细胞畸变率、染色体型畸变率、细胞总畸变率、微核率、微核细胞率均显著高于非吸烟组。表明吸烟是诱发人体遗传物质损伤的重要诱变因素之一。
英文摘要:
      Using two interrelated observation indices——chromosomal aberration and micronucleus analysis in peripheral blood lymphocytes to reflect damages of genetic material,were used to observe the status of genetic material damage in male smokers at the same time. The results showed that there were significant increase in hyperpolid cell rate, chromatid and chromosome aberration rates, total aberant cell rate and frequency of micronucleated cells as well as micronuleus in smoking group when compared to non-smoking group. This findings showed that cigarette smoking is one of the important mutagenic factors which caused damage to human genetic materials.
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