This paper reported an epidemiological investigation on human and animal infection to Eperythrozoon in 5 provinces. The results showed that Eperythrozoon infection existed in human as well an in animals in those provinces. Due to geographical variation,the infection rates were different. The infection rate was not associated with sex and age in human. The overall infection rate of different Eperythrozoonoses was higher than in healthy humans. The cases of Eperythrozoonoses among human and pig-herd were reported in this paper.