| 刘长云,童祥华,杜玉华,傅兴江,郑国华,马洪美.先天性心脏病的遗传流行病学研究[J].中华流行病学杂志,1997,18(4):224-226 |
| 先天性心脏病的遗传流行病学研究 |
| A Study on the Genetic Epidemiology of Congenital Heart Disease |
| 收稿日期:1996-09-12 出版日期:2021-06-09 |
| DOI： |
| 中文关键词: 遗传度 流行病学 先天性心脏病 |
| 英文关键词: Heritability Epidemiology Congenital heart disease |
| 基金项目:本课题为山东省计生委资助 |
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| 中文摘要: |
| 为探讨先天性心脏病的遗传方式，对375例先天性心脏病进行了遗传流行病学研究，结果显示该病一级亲属患病率为6.9%，遗传度66.13%±1.13%；二级亲属患病率为1.7%，遗传度为38.25±8.3%，一、二级亲属加权平均遗传度为65.65±1.09%，遗传因素较为重要。在各级亲属患病中，患病率依次为一级亲属（6.9%）、二级亲属（1.7%）、一般群体（0.86%）。所以该病基本符合多基因遗传方式，遗传在决定先天性心脏病的易患性上起主要作用。 |
| 英文摘要: |
| In order to explore the genetic model of congenital heart disease (CHD),375 individuals of CHD were investigated.The results showed that the incidence of primary relatives was 6.9%, the heritability was 66.13 ±1.13%, the incidence of secondary relatives was 1.7% and the heritability was 38.25±8.3% respectively.The average heritability among primary,secondary relatives was 65.65±1.09% which suggested that the genetic factor played an important role in pathogenesis. The sequence of the incidence in the relatives showed:primary relatives (6.9%)> secondary relatives (1.7%)> distant relatives (0.86%) and was in accordance with polygenic incidence,suqqesting that gene play an important role in the liability variation of CHD. |
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