文章摘要
刘长云,童祥华,杜玉华,傅兴江,郑国华,马洪美.先天性心脏病的遗传流行病学研究[J].中华流行病学杂志,1997,18(4):224-226
先天性心脏病的遗传流行病学研究
A Study on the Genetic Epidemiology of Congenital Heart Disease
收稿日期:1996-09-12  出版日期:2021-06-09
DOI:
中文关键词: 遗传度;流行病学;先天性心脏病
英文关键词: Heritability;Epidemiology;Congenital heart disease
基金项目:本课题为山东省计生委资助
作者单位
刘长云 山东省潍坊医学院附属医院儿科 261031 
童祥华 山东省潍坊医学院附属医院儿科 261031 
杜玉华 潍坊市计划生育研究所 
傅兴江 山东省潍坊医学院附属医院儿科 261031 
郑国华 山东省潍坊医学院附属医院儿科 261031 
马洪美 山东省潍坊医学院附属医院儿科 261031 
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中文摘要:
      为探讨先天性心脏病的遗传方式,对375例先天性心脏病进行了遗传流行病学研究,结果显示该病一级亲属患病率为6.9%,遗传度66.13%±1.13%;二级亲属患病率为1.7%,遗传度为38.25±8.3%,一、二级亲属加权平均遗传度为65.65±1.09%,遗传因素较为重要。在各级亲属患病中,患病率依次为一级亲属(6.9%)、二级亲属(1.7%)、一般群体(0.86%)。所以该病基本符合多基因遗传方式,遗传在决定先天性心脏病的易患性上起主要作用。
英文摘要:
      In order to explore the genetic model of congenital heart disease (CHD),375 individuals of CHD were investigated.The results showed that the incidence of primary relatives was 6.9%, the heritability was 66.13 ±1.13%, the incidence of secondary relatives was 1.7% and the heritability was 38.25±8.3% respectively.The average heritability among primary,secondary relatives was 65.65±1.09% which suggested that the genetic factor played an important role in pathogenesis. The sequence of the incidence in the relatives showed:primary relatives (6.9%)> secondary relatives (1.7%)> distant relatives (0.86%) and was in accordance with polygenic incidence,suqqesting that gene play an important role in the liability variation of CHD.
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