文章摘要
张红红,陶国枢,吴青,刘建伟,高宇红.我国汉族妇女维生素D 受体基因多态性和骨质疏松关系的研究[J].中华流行病学杂志,1998,(1):12-14
我国汉族妇女维生素D 受体基因多态性和骨质疏松关系的研究
Preliminary Studies on the Relationship between Vitamin D Receptor Genepolymorphism and Osteoporosis in Chinese Women
  
DOI:
中文关键词: 维生素D 受体;骨质疏松;基因型;聚合酶链反应
英文关键词: Vitamin D receptor; Osteoporosis; Genotype; Polymeras chain reaction(PCR)
基金项目:国防科工委科技基金资助项目
作者单位
张红红 解放军总医院老年医学研究所, 北京100853 
陶国枢 解放军总医院老年医学研究所, 北京100853 
吴青 解放军总医院老年医学研究所, 北京100853 
刘建伟 解放军总医院老年医学研究所, 北京100853 
高宇红 解放军总医院老年医学研究所, 北京100853 
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中文摘要:
      旨在探讨维生素D 受体(VDR)基因多态性与骨质疏松的关系, 采用聚合酶链反应限制性片段长度多态性技术对162 例健康汉族中老年妇女和17 例骨质疏松患者的VDR 基因进行分型, 并计算其基因频率分布。结果:正常对照组VDR 基因bb 、Bb 、BB 基因型分别为91.36%、8.64%、0%|骨质疏松组分别为82.35 %、17.65 %、0%, 两组各型均无显著性差异。VDR 基因多态性具有种族差异性, 就目前调查例数而言, 我国汉族人骨质疏松与BB 基因型无明显相关性。
英文摘要:
      The relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis were studied.The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 162 healthy postmenopausal women and 17 patients with osteopo rosis.The genotype frequencies of VDR were calculated later with Hardy-Weinberg equilibrium formula.The results showed that in controls,the bb,Bb,and BB genotype accounted for 91.36%, 8.64%, and 0% respectively.Of those patients with osteoporosis,they were 82.35%, 17.65%, and 0% respectively.The results suggested that there was no association between VDR genotype and osteoporosis noticed.
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