文章摘要
朱晓平,卢桂静,欧淑其,刘庆武.非洛地平缓释片对原发性高血压氧自由基及胰岛素抵抗的影响[J].中华流行病学杂志,1998,(1):30-32
非洛地平缓释片对原发性高血压氧自由基及胰岛素抵抗的影响
Ef fects of Plendil on SerumOxygen Free Radicals and Insulin Resistance in Patients with Essential Hypertension
  
DOI:
中文关键词: 高血压;非洛地平;胰岛素
英文关键词: Hy pertension; Plendil; Insulin
基金项目:
作者单位
朱晓平 水利部北京总医院 100036 
卢桂静 湖南医科大学湘雅医院心内科 
欧淑其 湖南医科大学湘雅医院心内科 
刘庆武 湖南医科大学湘雅医院心内科 
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中文摘要:
      为评价非洛地平缓释片对原发性高血压氧自由基及胰岛素抵抗的影响, 观察30 例轻、中度非肥胖原发性高血压患者口服非洛地平缓释片治疗30 天后, 对血清脂质过氧化物、超氧化物岐化酶、胰岛素敏感指数的影响。结果:①原发性高血压患者血清超氧化物岐化酶活力、胰岛素敏感指数较正常人明显下降, 血清脂质过氧化物、胰岛素水平明显升高, 服药后患者均恢复正常|②降压作用显著, 对心率无明显影响|③对空腹血糖、血脂无影响。作者认为非洛地平缓释片是一种安全、有效的抗高血压药物, 并具有抗氧化和改善胰岛素敏感性的作用。
英文摘要:
      To evaluate the effects of plendia on oxygen free radicals and insulin resistance in patients with essential hyper tension, thirty non-obesive moderate hypertensive patients were treated with plendil for 30 days.Antihyper tensive effect and effects on serum lipid peroxide (LPO), superoxide dismutase (SOD), insulin sensitivity index (ISI)were studied.Results showed:①SOD activity and I SI decreased but contents of LPO and insulin increased in the treatment group.After a course of plendil therapy the above mentioned parameters fell to normal ranges.②Plendil had obvious antihyper tensive effect but with no significant changes in heartrate.③Plendil had no significant effect on fasting blood glucose and lipids.Plendia was an effective and safe drug for treatment of essential hyper tension.It also had the effects of antioxidation which improved the sensitivity to insulin.
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