文章摘要
袁曾麟,李凤祥,李亚楠,石继春.我国人群中抗b型流感嗜血杆菌多糖抗体水平的调查[J].中华流行病学杂志,1999,20(1):42-44
我国人群中抗b型流感嗜血杆菌多糖抗体水平的调查
The investigation of natural antibody level toHaemophilus influenzae type b polysaccharide in China
收稿日期:1998-06-09  出版日期:2014-09-16
DOI:
中文关键词: b型流感嗜血杆菌多糖  自然抗体  放射免疫法
英文关键词: Hib-PRP  Natural antibody  Radio immunoassay
基金项目:
作者单位
袁曾麟 中国药品生物制品检定所, 北京 100050 
李凤祥 中国药品生物制品检定所, 北京 100050 
李亚楠 中国药品生物制品检定所, 北京 100050 
石继春 中国药品生物制品检定所, 北京 100050 
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中文摘要:
      目的 调查中国人群中抗流感嗜血杆菌多糖(Hib-PRP)自然抗体水平,为合理使用 Hib菌苗提供资料。方法 从7个省市收集1596份不同年龄组健康人群血清标本,用放射免疫方法检测抗 Hib-PRP自然抗体水平。结果 甘肃、贵州、江西等地5岁以下婴幼儿平均抗体水平<0.1μg/ ml,上海、广西、黑龙江等地相对较高。脐带血平均抗体含量为0.36μg/ ml,6月~5岁儿童平均抗体含量为< 0.15μg/ml,6岁至成人则达1~1.5μg/ml。结论 中国人群对Hib疾病的群体免疫力不高。6月~5岁儿童自然抗体水平最低,为 Hib疾病的高危人群。
英文摘要:
      Objective Investigation of natural antibody level to Haemophilus influenzae type b polysaccharide in China.Methods 1596 sera samples from cord(55 sera), infants(1383 sera), children (66 sera), adult (52 sera) and elderly (40 sera) were collected from different provinces and the natural antibody level to PRP was measured with a standardized radio immunoassay 125I-labeled PRP.Results Antibody level of infants under 5 year olds in different provinces was different. Levels of infants from Gansu, Guizhou, Jiang xi province were lower (≤0.07μg/ml)than from Shanhai, Guangxi and Heilognjiang. Comparison of antibody levels with different age groups showed that infants aged 6 months to 5 years having the lowest antibody level (<0.15μg/ ml). The level increased rapidly during 6-10 years of age (≥1.0μg/ ml). The levels of adults and elderly were about 1-1.5μg/ml.Conclusion General immunity against Hib disease were low in Chinese population. Children aged 6 months to 5 years old with lowest natural antibody level to PRP were the population under high risk.
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