| 赵惠芬,李莉,刘晓红.小儿肺炎支原体肺炎的细胞免疫和流行病学分析[J].中华流行病学杂志,1999,20(1):47-49 |
| 小儿肺炎支原体肺炎的细胞免疫和流行病学分析 |
| Cellullar immunity and epidemiologic analysis of pediatric patients with Mycoplasma pneumonia |
| 收稿日期:1998-10-16 出版日期:2014-09-16 |
| DOI： |
| 中文关键词: 支原体.肺炎 细胞免疫 白细胞介素受体 |
| 英文关键词: Mycoplasma pneumonia Celluler immunity Interleukin recepter |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨肺炎支原体肺炎的发病机理，特别是与机体免疫功能紊乱的关系。方法对９０例住院的支原体肺炎患儿，根据其 Ｘ 线肺部受侵程度，分为重症组和轻症组，并设立了对照组，分别检测了各组极期和恢复期的 Ｔ 细胞亚群、血清可溶性白细胞介素－２ 受体（ＳＩＬ－２Ｒ）及天然杀伤细胞（ＮＫ) 数。结果 肺炎支原体肺炎极期和恢复期 ＣＤ４ 均下降，ＣＤ８ 极期和恢复期均上升（ｔ ＝ ２．６３，２．６６ 和２．７７，３．３６，Ｐ＜ ０.０５)。全部病人，无论极期还是恢复期 ＳＩＬ－２ Ｒ 均显著高于正常，而在病的极期变化尤为明显（ｔ＝ ５．２６，３．１９,Ｐ＜ ０.０１）。检测还显示：ＳＩＬ－２Ｒ 与病情有关，病情越重，增高越明显。结论 患支原体肺炎时存在细胞免疫功能紊乱，且检测 ＳＩＬ－２Ｒ 的水平可作为监测其严重程度的指标。流行病学资料表明发病年龄以１０ ～１４ 岁为多发。 |
| 英文摘要: |
| Objective To understand the of immuno-reactions of pediatrics patients with Mycoplasma pneumonia.Methods 90 patients suffered from M. pneumonia were administered and divided into three groups: mild group, severe group, and normal control group. T cell subset parameters, natural killer cell and the serumsoluble interleukin-2 recepter of all of above were determined.Results Data showed: CD4 decreased at both acute and recovery stage of M. pneumonia, while CD8 remar kably increased (t=2.63, 2.66, 2.77, 3.36, P<0.05). SIL-2R level of all patients also greatly increased (t=5.26, 3.19, P P <0.01), especially in the serious group.Conclusion There are disturbances of cell-immune in M.pneumonia. The level of SIL-2R can serve as monitor on the degree of severeness of M. pneumonia. The incidence M. pneumonia appeared highest in the 10-14 year-old group. |
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