文章摘要
崔怡辉,庄辉,孙德贵,梁争论,李奎,杜珩,朱永红.某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究[J].中华流行病学杂志,1999,20(5):273-276
某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究
A cross-sectional study on HAV,HBV,HCV,HEV and HGV infection in a rural population
收稿日期:1999-03-25  出版日期:2014-10-17
DOI:
中文关键词: 病毒性肝炎;传播途径;流行因素;献血浆;家庭聚集性
英文关键词: Viral hepatitis;Mode of transmission;Risk factors;Plasma donation;Family clustering
基金项目:
作者单位
崔怡辉 北京医科大学微生物学系,100083 
庄辉 北京医科大学微生物学系,100083 
孙德贵 河北省固安县卫生防疫站 
梁争论 中国药品生物制品检定所 
李奎 北京医科大学微生物学系,100083 
杜珩 北京医科大学微生物学系,100083 
朱永红 北京医科大学微生物学系,100083 
摘要点击次数: 674
全文下载次数: 0
中文摘要:
      目的:了解某农村人群甲、乙、丙、戊和庚型肝炎病毒的感染状况及其流行特点。方法:应用酶联免疫试验 (EIA)检测血清抗 -HAV、HBsAg、抗 -HBs、抗 -HBc、抗 -HCV、抗 -HEV和抗 -HGV,并对抗 -HGV阳性者应用套式逆转录聚合酶链反应法 (RT -nPCR)检测HGVRNA。结果:该人群抗 -HAV、抗 -HCV、抗 -HEV和抗 -HGV流行率分别为 86.9%、11.5 %、2.9%和 1.8%,HBsAg阳性率为8.0%,HBV总感染率为 5 4.8%。HAV以 5岁以下儿童感染率最低 ( 35.0% ),到 10岁时 85.0%的儿童已感染HAV。HBsAg阳性率呈现两个高峰,分别在 5~ 9岁和 40~ 49岁年龄组;HBV总感染率到 10岁时为 5 5.0%,然后随年龄增长而上升。HCV感染主要集中在 2 0~ 49岁年龄组 (占 77.8% )。各型肝炎病毒男女感染率无明显差异。献浆次数、年限与HCV、HEV、HGV感染呈正相关。HBsAg、抗 -HBc、抗 -HCV呈现家庭聚集性,但仅HBsAg呈现母亲与子女相关。抗 -HCV阳性者中ALT异常率 ( 15.9% )显著高于抗 -HCV阴性者 ( 1.2 %,P <;0.01)。结论 :该人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病学特点;献血浆是该人群HCV、HEV和HGV感染的主要危险因素;抗 -HCV阳性者多伴有肝损害。
英文摘要:
      Objective:To study the epidemiological characteristics of HAV,HBV,HCV,HEVand HGV infections in a rural population.Methods:Enzyme immunoassays were used for detection ofanti-HAV,HBsAg,anti-HBs,anti-HCV,anti-HEV and anti-HGV.Anti-HGV positive sera were further tested for HGV RNA using a reverse transcription nested PCR.Results:The prevalence rates of anti-HAV,HBsAg,anti-HCV,anti-HEV,anti-HGV in the studied population were86.9%,8.0%,11.5%,2.9%and 1.8%,respectively.The total infection rate of HBV was 54.8%.The HAV infection rate of children below 5 was the lowest(35.0%)as compared with other age groups.85.0%of children at 10years old had already been infected with HAV.The HBsAg positive rate showed two peaks at 5-9 and 40-49 age groups.The total infection rate of HBV was 55.0%in the age group less than 10years old and increased with age.HCV infection mainly occurred in the age group of 20-49(77.8%).The prevalence rates of anti-HCV,anti-HEV and anti-HGV increased with the frequencies and duration of plasma donation.Family clusterings of HBsAg,anti-HBc and anti-HCV were observed.However,only with HBsAg showed a correlation between mothers and their offspring.The frequency of abnormal ALT in anti-HCV positive individuals was significantlyhigheras compared with that in those with negative anti-HCV.No difference was observed in the frequencies of elevated ALT between those with or without HAV,HBV,HEV and HGV markers.Conclusion:HAV,HBV,HCV,HEV and HGV infections had different epidemiological characteristics.Plasma donation was the major risk factor for HCV,HEV and HGV infections in this population under study.Anti-HCV positive individuals are more likely to have active HCV infection.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭