文章摘要
杨松,谈永飞,喻荣彬,彭俊,沈靖,姚才良.胆石病家族聚集性及遗传方式的研究[J].中华流行病学杂志,1999,20(5):293-295
胆石病家族聚集性及遗传方式的研究
A study on the genetic epidemiology of gallstone disease
收稿日期:1999-04-25  出版日期:2014-10-17
DOI:
中文关键词: 胆石病;遗传方式;遗传度
英文关键词: Gallstone disease;Genetic model;Heritability
基金项目:
作者单位
杨松 江苏省宜兴市人民医院,214200 
谈永飞 江苏省宜兴市人民医院,214200 
喻荣彬 南京医科大学公共卫生学院 
彭俊 江苏省宜兴市人民医院,214200 
沈靖 南京医科大学公共卫生学院 
姚才良 南京医科大学公共卫生学院 
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中文摘要:
      目的:探索胆石病家族聚集性及遗传方式。方法:采用遗传流行病学病例对照研究方法:,对 317个家系 ( 138个胆石病先证家系和 179个对照家系 )进行研究。结果:病例组一级亲属总的胆石病患病率为 2.60%,显著高于对照组的 1.29% ( χ2 =4.78,P =0.02 88);分离比为显著低于 0.2 5,不符合单基因遗传疾病的特征;遗传度估算显示,该病一级亲属中,遗传度为2 1.80%,其中男性亲属的遗传度为 36.34%,显著高于女性亲属的 14.15 %。结论:在胆石病的病因中,遗传因素起一定作用,尤其对男性作用更为明显。
英文摘要:
      Objective:To explore the genetic model of gallstone disease(GD).Methods:A case-control study including 317 pedigrees(138 cases and 179 controls)was conducted.Results:The prevelence of the first-degree relatives in cases was 2.60%,significantly higher than that noticed in controls(1.29%).Segregation analysis showed that GD did not possess the characteristics of monogenic model.Meanwhile the results showed that the heritability of the first-degree relatives was 21.80%,with male 36.34%which was significantly higher than the females(14.15%).Conclusion:This study indicated that the genetic factors played an important role in the occurrence of GD,especially in males.
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