| 汪萱怡,马景臣,张勇,张英林,韩常全,邢占春,陈吉朝,张玉伟,赵守军,顾惠心,徐志一.甲型肝炎减毒活疫苗加强免疫效果的初步研究[J].中华流行病学杂志,2000,21(2):124-127 |
| 甲型肝炎减毒活疫苗加强免疫效果的初步研究 |
| Primary study on immunologic effect of live attenuated hepatitis A vaccine (H2 strain)after booster dose |
| 收稿日期:1999-10-21 出版日期:2014-09-16 |
| DOI： |
| 中文关键词: 甲型肝炎 减毒活疫苗 加强免疫 免疫原性 |
| 英文关键词: Hepatitis A Live attenuated vaccine Booster Immunogenicity |
| 基金项目:“ 九五” 国家医学科技攻关项目(96-906-03-01) |
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| 中文摘要: |
| 目的 观察甲型肝炎 (甲肝 )减毒活疫菌 (10 7. 0 TCID50 )加强免疫效果, 并同活疫苗一针法结果进行比较. 方法 在河北省正定县选择 42名经事先检测甲肝抗体阴性的易感儿童, 分别于0、2和 6个月各接种一剂甲肝减毒活疫苗, 并于接种后 1、2、6、7、9和 12个月采集血清标本, 观察免后抗体动态变化. 结果 第 1剂接种后 1个月抗体阳转率达 81. 4%, 第 2剂免后抗体阳转率达 10 0 %, 抗体水平于第 3剂免后 1个月达高峰, 为 2 739mIU/ml, 以后呈下降趋势, 免后 12个月抗体阳转率仍为 10 0 %, 抗体水平下降至 979mIU/ml. 结论 甲型肝炎减毒活疫苗加强免疫能诱导良好的免疫回忆反应, 其免疫学效果同史克灭活疫苗相当, 而明显高于活疫苗一针法. 活疫苗加强免疫中, 初免是基础. 活疫苗加强免疫会提高疫苗保护效果, 并延长疫苗的免疫持久性 |
| 英文摘要: |
| Objective To study the immunologic effect of live attenuated hepatitis A vaccine (H2 Strain, 107. 0TCID50)after booster and to compare with the Results of 1 dose live attenuated hepatitis A vaccine (H2 Strain, 107. 0TCID50). Methods 42 susceptibles with negative anti-HAV were selected in Zheng ding, Hebei province. Each subject received 3 do ses live attenuated hepatitis A vaccine at 0, 2, 6 months and was bled at 1, 2, 6, 7, 9, 12 months after vaccination. Results The seroconversion rate at 1 month after the first dose was 81. 4% and reached 100% after the second dose. GMT arrived the peak 2 739mIU/ml at one month after the third dose, before stared declining. The seroconversion rate kept 100% at 12 months after the first dose, but GMT decreased to 979 mIU/ml. Conclusion The first dose worked as the base of boostering. A booster dose of live attenuated hepatitis A vaccine could induce secondary immune response well. The immunologic effect after booster dose could match the effect with inactivated vaccine and was better than the Results of 1 dose live attenuated hepatitis A vaccine. The program seemed to be useful to the protective effect and the immuno-persistence. |
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