文章摘要
连民,刘颖,俞顺章,陈传炜,周学富,周余春,丁保国,王如鸿.饮水中微囊藻毒素对人群健康影响的横断面研究[J].中华流行病学杂志,2000,21(6):437-440
饮水中微囊藻毒素对人群健康影响的横断面研究
A cross-sectional study on the effects of microcystin in drinking water to the health of human beings
收稿日期:2000-04-07  出版日期:2014-09-16
DOI:
中文关键词: 饮水;微囊藻毒素;流行病学
英文关键词: Drinking;Microcystin;Epidemiology
基金项目:国家自然科学基金资助项目(39730380 )
作者单位
连民 上海医科大学预防医学研究所环境医学与分子生物研究室 200032 
刘颖 流行病学研究室 
俞顺章 上海医科大学预防医学研究所环境医学与分子生物研究室 200032 
陈传炜 上海医科大学预防医学研究所环境医学与分子生物研究室 200032 
周学富 江苏省泰兴市卫生防疫 
周余春 江苏省泰兴市卫生防疫 
丁保国 江苏省泰兴市卫生防疫 
王如鸿 江苏省泰兴市卫生防疫 
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中文摘要:
      目的 初步了解饮水中微囊藻毒素 (MC)对人体健康的影响。方法 采用横断面研究方法,在泰兴肝癌高发区两个不同饮水类型的学校里分别随机抽取 111名和 92名学生,对其进行调查,并采集静脉血,检测血清中乙型肝炎病毒 (HBV)感染标志物及血清丙氨酸氨基转移酶 (ALT)、γ 谷氨酰转移酶 (γ GT)、碱性磷酸酶 (ALP)水平。按照HBV感染进行分层,比较两组人群血清三种酶学水平的差异。结果 两组人群三种酶学指标差异存在显著性 (P<0.0 1),暴露组高于对照组。结论 长期饮用有微囊藻毒素污染的水可能对肝脏有损害作用,引起血清中某些肝脏酶学指标的升高。
英文摘要:
      Objective To understand the effects of micr ocystin(MC) in drinking water on health of human beings. Methods In Taix ing,a cross-sectional study was conducted in two middle schools with differ ent types of drinking water, from which 111 and 92 students were randomly selected and investigated. Blood samples from all individuals were collected and tested for serum HBsAg, HBeAg, ant-i HBe, ant-i HBs, ant-i HBc w ith enzyme linked immunoabsorbent assay and for serum alanine aminotransferase ( ALT ), C- glutamyltransferase ( C-GT ) and alkaline phosphatase ( ALP) contents by color imetr y. These levels of enzymes in sera were compar ed after the students w er e stratified acco rding to the status of HBV infection. Result With the ex clusion of the effect of HBV infection, thr ee enzymes levels in ser a betw een two groups of students show ed significant differ ences ( P < 0. 01), much hig her in ex posure group than those in control g roup. Conclusion MC w as possibly harmful to human beings in drinking w ater and induced the contents of some enzymes fr om the liv er of human beings to increase in sera.
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