| 刘爱萍,詹思延,李立明.低密度脂蛋白受体基因多态性与高脂血症的关系[J].中华流行病学杂志,2001,22(1):30-33 |
| 低密度脂蛋白受体基因多态性与高脂血症的关系 |
| The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia |
| 收稿日期:2000-01-14 出版日期:2014-09-16 |
| DOI： |
| 中文关键词: 低密度脂蛋白受体 基因多态性 高脂血症 高血压 |
| 英文关键词: Low density lipoprotein receptor Gene polymorphism Hyperlipidemia Essential hypertension |
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| 摘要点击次数: 2608 |
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| 中文摘要: |
| 目的: 探讨上海市城市社区高血压人群中低密度脂蛋白受体 (lowdensitylipoproteinreceptor,LDL R)基因多态性与高脂血症的关系。方法: 运用聚合酶链反应-限制性内切酶片段长度多态性 (PCR RFLP)技术检测 107例高脂血症、104例临界高脂血症和 108例正常血脂的LDL R基因多态性。结果: 发现LDL R基因型有 3种，即 (+ / + )型、(+ / - )型、(- / - )型。男性，3组均有(+ / + )基因型，高脂血症组 2例，临界高脂血症组和正常血脂组均为 1例。高脂血症组、临界高脂血症组、正常血脂组 (+ / - )基因型频率分别为 41.18%、46.15 %、19.05 %，3组 (+ )等位基因频率分别为 24.51%、25.00 %、11.11%。高脂血症组和临界高脂血症组 (+ / - )基因型频率及 (+ )等位基因频率均高于正常血脂组 (P <0.0 5 )；女性，3组均无 (+ / + )基因型，且 3组基因型及等位基因频率差异无显著性 (P <0.05 )。单因素和多因素非条件logistic回归分析显示：男性LDL RAvaⅡ (+ / +，+ /- )基因型与高脂血症 (OR =3.08)、临界高脂血症 (OR =3.82 )关联显著。结论: 上海市城市社区高血压人群中男性高脂血症LDL R基因 (+ / - )基因型显著高于正常血脂组，(+ )等位基因频率也明显高于正常血脂组，说明LDL R基因多态性与高脂血症的易感基因之一。 |
| 英文摘要: |
| Objective: To study the relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia in the population with essential hypertension. Methods: People with different lipid levels including 107 hyperlipidemia, 104 at margin level and 108 normal were recruited in the study. Their polymorphisms of LDL-R gene were analyzed using PCR-RFLP. Results: There were three kinds of genotype: (+/ +)、(+/ -)、(-/ -). In male, the frequencies of the(+/ -)in three study groups were shown as follows: 41.18% in hyperlipidemia, 46.15 % in margin level, 19.05% in normal lipid. The frequency of (+) allele was significantly higher in hyperlipidemia than that in normal lipid (24.51 %, 25.00% and 11.11 %, respectively). In women, the differences were not statistically significant. The nonconditional univariate and multivariate logistic regression analysis demonstrated that (+) allele of AvaⅡ polymorphism of LDL-R was a genetic marker of male' s hypercholesterolemia. Conclusions: The frequency of (+/ -)hyperlipidemia in males was higher than that in normal lipid group and the (+)allele in male hyperlipidemia was significantly more frequant seen than that in normal lipid group. These results suggested that polymorphisms of LDL-Rg enemight play an independent role of risk factor for hyperlipidemia. |
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