文章摘要
董惠洁,郑庆斯.我国碘盐普及地区新生儿脐带血促甲状腺激素水平测定及其应用的探讨[J].中华流行病学杂志,2002,23(4):250-252
我国碘盐普及地区新生儿脐带血促甲状腺激素水平测定及其应用的探讨
Study on the neonate umbilical cord blood thyroid stimulating hormone level in the universal iodized salt areas and its application
收稿日期:2001-12-17  出版日期:2014-09-18
DOI:
中文关键词: 促甲状腺激素;新生儿脐带血;碘缺乏病
英文关键词: Thyroid stimulating hormone (TSH) Neonate umbilical cord blood Iodine deficiency disorders(IDD)
基金项目:
作者单位
董惠洁 中国疾病预防控制中心传染病预防控制所碘缺乏病室, 北京 100020 
郑庆斯 中国疾病预防控制中心传染病预防控制所碘缺乏病室, 北京 100020 
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中文摘要:
      目的调查中国碘盐普及地区新生儿脐带血促甲状腺激素 (TSH)水平,提出新生儿脐带血TSH的正常值范围 ,并探讨该指标的应用。方法选取普及碘盐且孕妇碘营养情况良好的7省市,采集孕妇尿样及其新生儿脐带血血样,测定孕妇尿碘和新生儿脐带血TSH值。结果共测定152 4名孕妇的尿碘及其新生儿脐带血TSH值 ,结果显示孕妇尿碘中位数为246.0μgL,新生儿脐带血TSH中位数为3.58mUL;不同地区、不同分娩方式的新生儿脐带血TSH水平差异存在显著性。结论生儿脐带血TSH受应激反应和分娩方式等诸多因素影响 ,且不具规律性 ,尚难以确定其正常值范围 ,因此不宜作为碘缺乏病监测指标 ,但可继续用于新生儿甲状腺机能减低的筛查。
英文摘要:
      Objective To investigate the neonatal umbilical cord blood thyroid stimulating hormone (TSH) level in the universal iodized salt areas and put forward the cut point, then analyze its application. Methods Seven provinces were selected where the pregnant women having satisfied urinary iodine levels, then the urinary samples of pregnant women and the neonates cord blood were collected for urine iodine and TSH tests, and the relative factors were also recorded. Results Total 1 524 urine and cord blood samples were collected from pregnant women and their new borns respectively. The median urinary iodine of pregnant women was 246.0 μg/L, and the median TSH was 3.58 mU/L. The TSH level among seven areas and the neonatal delivery type varied significantly. Conclusions The neonatal cord blood TSH was influenced by several factors and could not be controlled, thus not be suitable as a iodine deficiency disorders surveillance indicator.
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