文章摘要
卢亦愚,严菊英,周敏,姜晓路.浙江省与日本A3型流行性感冒病毒株的血凝特性及HA1序列比较[J].中华流行病学杂志,2003,24(1):15-18
浙江省与日本A3型流行性感冒病毒株的血凝特性及HA1序列比较
Comparison of characterization of hemagglutination and HA1 sequence of currently circulating strains of influenza A(H3N2) virus in Zhejiang province and in Japan
收稿日期:2002-02-06  出版日期:2014-09-15
DOI:
中文关键词: 流行性感冒  血凝素重链序列  血凝特性
英文关键词: Influenza  Hemagg lutinin 1(HA1)sequence  Hemagglutination characteristics
基金项目:
作者单位
卢亦愚 浙江省疾病预防控制中心病毒学研究所, 杭州 310009 
严菊英 浙江省疾病预防控制中心病毒学研究所, 杭州 310009 
周敏 浙江省疾病预防控制中心病毒学研究所, 杭州 310009 
姜晓路 浙江省疾病预防控制中心病毒学研究所, 杭州 310009 
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中文摘要:
      目的: 比较近年来在浙江省与日本流行的A3(H3N2)型流行性感冒(流感)毒株的血凝特征与血凝素重链(HA1)区域的序列差异。方法: 对浙江省不同性状的流感代表株进行了抗原性分析, 并与日本同期的毒株作了血凝特性及HA1区域的氨基酸序列比较分析。结果: 近年在浙江流行的A3型流行株, 其抗原性已发生较大变异, 其中绝大部分是对鸡红细胞缺乏凝集特性的O相毒株, 它与A武汉35995株二者在HA1区域的氨基酸同源性仅为94.82 %, 存在较大差异, 这些O相毒株可以通过在MDCK细胞上的传代而转变为D相毒株, 日本的同期毒株, 其情况也相似。结论: A3型流感病毒在HA1区域发生的变异, 是近年引起浙江省流感流行的主要因素。
英文摘要:
      Objective: To compare the characterization of hemagglutination and the sequence of HA1 region of the influenza A(H3N2)virus in Zhejiang province and Japan in recent years. Methods: Hemag glutinin antigenic analysis of influenza A(H3N2)viruses which were isolated in Zhejiang province was carried out and to compare their characterization of hemag glutinatio n and the sequence of amino acids in HA1 region with the virus strains from Japan during the same period. Results: The antigenicity and the amino acid sequence in HA1 region of the virus strains prevalent in Zhejiang in recent years have changed to some extent. Most of the virus strains were lack of hemagg lutination reaction to chicken red blood cell and became “O” phase virus strains. The amino acid sequence of HA1 region of the virus strains exhibited only 94.82 % of its homology with that of A Wuhan 35995 strain. The virus strains of Japan in the same period showed similar characteristics. Conclusion: HA1 gene varia tion of influenza A (H3N2) viruses was the main cause leading to the spread of influenza in the last years.
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