文章摘要
陈胤忠,姜仁杰,俞文祥,李承惠.建立群体免疫屏障控制甲型肝炎流行的效果研究[J].中华流行病学杂志,2003,24(5):366-369
建立群体免疫屏障控制甲型肝炎流行的效果研究
Study on the effects of controlling hepatitis A epidemics by building the colony immune defence
收稿日期:2002-09-13  出版日期:2014-09-18
DOI:
中文关键词: 疫苗  甲型肝炎病毒抗体  群体免疫屏障
英文关键词: Vaccine  Anti-HAV IgG  The colony immune defence
基金项目:江苏省卫生厅招标项目 (99011)
作者单位
陈胤忠 江苏省盐城市卫生防疫站 224002 
姜仁杰 江苏省盐城市卫生防疫站 224002 
俞文祥 江苏省盐城市卫生防疫站 224002 
李承惠 江苏省盐城市卫生防疫站 224002 
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中文摘要:
      目的大面积接种甲型肝炎(甲肝)疫苗,建立群体免疫屏障,控制甲肝周期性流行效果评价。方法对甲肝易感人群进行逐步免疫覆盖,并选择不同流行强度地区的人群进行抗HAVIgG监测,分析评价甲肝疫苗累计接种率与人群免疫水平、甲肝发病率之间的相关性。结果①1993~2000年8年间累计接种甲肝疫苗1981805人份,累计接种率为34.15%,学龄前儿童、中小学生、15~45岁年龄组人群累计接种率分别为84.46%、82.23%、15.14%。2000年甲肝发病率仅为8.26/10万。②1998年人群抗HAVIgG阳性率为74.24%,至2000年抗HAVIgG阳性率达83.68%,其中2~4、6~8、13~15、20~、30~39岁年龄组的抗HAVIgG阳性率已分别达到74.02%、68.49%、79.41%、85.71%、90.80%。③相关与回归分析,人群甲肝疫苗累计接种率与甲肝抗体阳性率存在正相关关系,r全市=0.91,F=15.10,P<0.03。结论大面积接种甲肝疫苗后,人群甲肝抗体阳性率达到85%左右,有效地构筑了甲肝的群体免疫屏障,阻断了甲肝后续的周期性流行,甲肝发病率控制在历史最低水平。
英文摘要:
      Objective To build the colony immune defence and to control the periodic epidemics of hepatitis A after a mass vaccination of live attenuated hepatitis A vaccine.MethodsThrough yearly observing the correlation of the accumulative inoculation rates of live attenuated hepatitis A vaccine,the crowd immune standard and the morbidity of hepatitis A after administered live attenuated hepatitis Avaccine among susceptible population and surveilling anti-HAV IgG in the different epidemic areas.Results(1)The accumulative inoculation rates of live attenuated hepatitis A vaccine was 34.15% in 8 years from 1993 to 2000,among w hich they were 84.46%,82.23% and 15.14%in the preschool children,primary and middle school student and 15-45 age groups respectively.The morbidity of hepatitis A decreased to 8.26/ 100000 in 2000.(2)The crowd positive rates of anti-HAV IgG were 74.24% in 1998 and 83.68% by 2000.Among which they were 74.02%,68 .49%,79.41%,85.71% and 90.80% in 2-4,6-8,13-15,20- and 30-39 age groups respectively.(3)The accumulative inoculation rates were 37.36%, 51.08% and 28.68% in the inspection areas of Tongtai,Binhai and Yandu respectively.The crowd positive rates of anti-HAV IgG in three inspect area were 85.71%,85.94% and 78.6 % respectively.It was noticed the correlation between the accumulative inoculation rates and the crowd positive rates of anti-HAV IgG was (rcity =0.91,F =15.10,P<0.03).Conclusion The results showed that the crowd positive rates of anti-HAV IgG had increased to 85% while,the colony immune defence of hepatitis A was effectively built to break the periodic epidemics of hepatitis A.The morbidity of hepatitis A decreased to the lowest level in the history
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