| 刘玮,张翠英,吴晓明,田磊,李春芝,赵秋敏,张泮河,杨淑梅,杨红,张习坦,曹务春.维生素D受体基因多态性与肺结核易感性的病例对照研究[J].中华流行病学杂志,2003,24(5):389-391,392 |
| 维生素D受体基因多态性与肺结核易感性的病例对照研究 |
| A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberclosis |
| 收稿日期:2002-07-30 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 结核,肺 维生素D受体基因 病例对照研究 |
| 英文关键词: Tuberculosis,pulmonary Vitamin D receptor gene Case-control study |
| 基金项目:国家自然科学基金资助项目 (30271144) |
|
| 摘要点击次数: 2633 |
| 全文下载次数: 876 |
| 中文摘要: |
| 目的探讨维生素D受体(VDR)基因多态性与中国汉族人群肺结核发病间的关系。方法采用病例对照研究设计,用聚合酶链反应限制性片段长度多态性分析(PCRRFLP)检测VDR基因中T/C多态性位点,对肺结核相关的环境因素进行问卷调查,并进行单因素分析和多因素logistic回归分析。结果对76例病例和171名对照进行了VDR的基因分型,VDRFF、VDRFf与VDRff三种基因型在病例组和对照组中的分布频率分别为38.2%、44.7%、17.1%和52.6%、40.9%、6.4%,其中ff基因型在病例组中的频率显著高于对照组,OR值95%CI:3.668(1.483～9.071);在多因素分析中调整卡介苗接种史和吸烟状况后,VDRff基因型与肺结核发病仍有显著性关联,调整OR值95%CI:3.036(1.117～8.253)。结论VDRff基因型可能是中国汉族人群肺结核病的易感基因型。 |
| 英文摘要: |
| Objective To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis .Methods Case-control study w as conducted.PCR-RFLP technique was used to detect the C/ T polymorphism in VDR gene.Information on related factors of tuberculosis was collected using a pre-tested questionnaire.Univariate and multivariate logistic analyses were conducted with SPSS software package.ResultsA sample of 76 cases and 171 controls w as studied.The genotype frequencies of VDR-FF,VDR-Ff and VDR-ff were 38.2%,44.7%,17.1% and 52.6%,40.9%,6.4% respectively.VDR-ff was significantly overrepresented in case group,the OR(95%CI) was 3.668(1.483-9.071)when comparing with FF genotype.The significant association remained after adjusting BCG immunization and smoking,the OR (95%CI)was 3.036(1.117-8.253).ConclusionThe VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population. |
|
查看全文
Html全文
查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
