文章摘要
吕筠,李立明,曹卫华,詹思延,胡永华.苯那普利致咳嗽不良反应的监测及其危险因素研究[J].中华流行病学杂志,2003,24(5):401-404,405
苯那普利致咳嗽不良反应的监测及其危险因素研究
Postmarketing surveillance of benazepri-l related cough and related risk factors analysis on hypertensives
收稿日期:2002-11-24  出版日期:2014-09-18
DOI:
中文关键词: 血管紧张素转换酶抑制剂  咳嗽  饮酒  吸烟  肾功能衰竭
英文关键词: Angiotensin converting enzyme inhibitor  Cough  Alcohol drinking  Smoking  Kidney failure
基金项目:国家“九五”科技攻关基金资助项目 (969060205 )
作者单位
吕筠 中国疾病预防控制中心 
李立明 北京大学医学部公共卫生学院流行病与卫生统计学系 100083 
曹卫华 中国疾病预防控制中心 
詹思延 中国疾病预防控制中心 
胡永华 中国疾病预防控制中心 
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中文摘要:
      目的研究苯那普利相关咳嗽不良反应的危险因素。方法对1831例高血压患者进行连续3年的用药观察,随访记录咳嗽不良反应发生情况,并嵌套病例对照研究,进行危险因素分析。结果服用苯那普利后半年内,咳嗽不良反应的发生率女性为18.35%,男性为12.11%。logistic回归分析显示,女性(OR=2.193,95%CI:1.500~3.206)、肾功能失代偿的女性(OR=3.432,95%CI:1.954~6.028)、女性65岁以上(OR=1.672,95%CI:1.040~2.688)、男性饮白酒100g/日以上(OR=2.478,95%CI:1.148~5.347)发生咳嗽不良反应的危险性增加。结论女性、老年、饮白酒、肾功能失代偿是苯那普利致咳嗽不良反应发生的可能危险因素,但不是主要的危险因素。
英文摘要:
      Objective To investigate the risk factors of benazepril related cough.Methods Case-control study nested in a community-based postmarketing surveillance was carried out One thousand eight hundred and thirty-one hypertensive patients screened from a Chinese community were recruited to take benazepril for 3 years.Demographic characteristics and behavior risks were investigated and the level of uric acid and creatinine were tested at baseline.Episodes of benazepril related cough during follow period were recorded.Results Within half a year of administration,the incidence rates of cough were as high as 18.35% in women and 12.11% in men.Incidence decreased significantly when time went by.Two years later of administration,first occurrences of cough were still seen.Based on logistic regression analysis,women were more likely to develop cough (OR= 2.193,95% CI:1.500-3.206).The association between decompensated kidney function and cough occurrence was only detected in women (OR =3.432,95% CI:1.954-6.028).Women aged 65 or more had 1.672 (95% CI:1.040-2.688) times risk than women aged 35 to 64 years.In men,the OR of developing cough was 1.689( 95%CI 0.976-2.924) for daily drinking alcohol less than 100 g but increased to 2.478( 95%CI:1.148-5.347) when drinking 100 g or more,but not the determinant ones.Conclusion Women,older age, drinking alcohol and decompensated kidne function were the possible risk factors for benazepril related cough, but not the determinant ones.
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