广西七城市围产儿先天畸形危险因素的病例对照研究

仇小强; 曾小云; 覃丹丹; 钟喜红; 林墨菊; 张宏丽; 黄栋

文章摘要

仇小强,曾小云,覃丹丹,钟喜红,林墨菊,张宏丽,黄栋.广西七城市围产儿先天畸形危险因素的病例对照研究[J].中华流行病学杂志,2003,24(6):512-515

广西七城市围产儿先天畸形危险因素的病例对照研究

A case-control study on the risk factor of perinatals' congenital malformations in seven cities of Guangxi

收稿日期:2002-09-17 出版日期:2014-09-18

DOI：

中文关键词: 围产儿先天畸形危险因素 logistic回归分析

英文关键词: Perinatals Congenital malformations Risk factors Analysis of logistic regression

基金项目:广西自然科学基金资助项目(9912026)

作者	单位
仇小强	广西医科大学公共卫生学院流行病教研室, 南宁 530021
曾小云	广西医科大学公共卫生学院流行病教研室, 南宁 530021
覃丹丹	广西医科大学公共卫生学院流行病教研室, 南宁 530021
钟喜红	南宁市卫生局
林墨菊	柳州市妇幼保健院
张宏丽	南宁市妇幼保健院
黄栋	广西医科大学公共卫生学院流行病教研室, 南宁 530021

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中文摘要:

目的探讨广西城区围产儿先天畸形的危险因素。方法随机抽取2000年在广西七城市所属62所医院(不包括郊区、县医院)出生的281例畸形儿和730名对照进行病例对照研究和单因素、多因素非条件logistic回归分析。结果先天畸形的主要危险因素是:多产次(OR=2.6),有妊娠合并症(OR=3.2),母亲妊娠前后接触化学制剂(OR=3.0),孕期服用镇静药(OR=10.2)、激素类药物(OR=9.4)、中成药(OR=2.5),母亲血型为AB型(OR=3.5)、A型(OR=2.2),母亲孕期情绪紧张、忧郁(OR=2.6),母亲职业为工人(OR=3.8)、农民(OR=3.0),父亲接触噪声(OR=5.7)、有慢性病(OR=2.8)。结论母亲孕期服镇静药、激素类药、中成药,情绪紧张、忧郁,多产次,有妊娠合并症,母亲妊娠前后接触化学制剂,母亲血型为AB型、A型,职业为工人、农民,父亲接触噪声、有慢性病等是围产儿先天畸形的危险因素。

英文摘要:

Objective To investigate the possible risk factors of congenital malformations in cities of Guangxi.Methods A case-control study was carried out on 281 cases of congenital malformations and 730 controls. Analysis of simple factor and multiple factors unconditional logistic regression were done.Results The analysis of simple factor and multiple factors showed that main risk factors of congenital malformations as multiple pregnancies (OR=2.6), pregnancy complications (OR=3.2), exposure to chemical substances before or during pregnancy (OR=3.0), taking sedatives (OR=10.2), hormone drug (OR=9.4) or Chinese herbal medicines (OR=2.5) during the early stage of pregnancy, mothers' blood type as AB (OR=3.5) or A (OR=2.2), mothers' emotion being nervous and melancholy (OR=2.6), mothers' occupation being workers (OR=3.8) or peasants (OR=3.0), fathers' exposure to noise (OR=5.7) or suffering from chronic diseases (OR=2.8).Conclusions Some risk factors were identified as having important effect on perinatal congenital malformations, including taking sedatives, hormone drug or Chinese herbal medicines during the early stage of pregnancy, mothers' emotion being nervous and melancholy,multiple pregnancies, pregnancy complications, exposure to chemical substances before or during pregnancies,mothers' blood type as AB or A, mothers' occupation being workers or peasants, fathers' exposure to noise or suffering from chronic diseases.

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