| 周枫,马泽恩,胡薇,冯宗亮,陈康林,秦光明,孙乔,刘刚,梁姝,何益新,刘石柱,阮玉华,邵一鸣.静脉吸毒共用注射器具方式和性行为与丙型肝炎病毒感染关系的研究[J].中华流行病学杂志,2004,25(4):329-332 |
| 静脉吸毒共用注射器具方式和性行为与丙型肝炎病毒感染关系的研究 |
| Study on the relationship between hepatitis C virus infection and sharing injection equipment,sexual behavior among injecting drug users |
| 收稿日期:2003-07-09 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 静脉吸毒 共用注射器具 肝炎病毒,丙型 性行为 |
| 英文关键词: Injection drug user Sharing injeclion equipment Hepatitis virlls C: Sexua1 behavior |
| 基金项目:国家“十五”科技攻关课题资助项目(2001 BA705B02);国家自然科学基金(30170823) |
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| 中文摘要: |
| 目的 了解四川省凉山州某地区静脉吸毒人群共用注射器具方式及性行为与丙型肝炎病毒(HCV)感染的关系。方法 以社区为基础使用标准化问卷调查静脉吸毒人群人口学特征和静脉吸毒共用注射器具方式、性行为情况;通过检测研究对象的HCV抗体确定是否感染HCV。结果 在静脉吸毒379人中,静脉吸毒人群HCV感染率为对71.0%(269/379)。单因素分析结果显示近3个月共用针头或注射器和既往感染梅毒在HCV感染方面差异有统计学意义。趋势性检验发现随着共用针头或注射器、共用洗针头或注射器水的频率以及共用注射器具伙伴数的增加HCV的感染率也在增加。多因素分析结果显示,近3个月共用针头或注射器。既往感染梅毒是HCV感染的危险因素,其OR值分别为1.468(95%CI:1.045～2.061)和2.914(95%CI:1.327～6.398)。未见性行为对HCV感染的影响。结论 需考虑采用定群血清流行病学研究来进一步阐明静脉吸毒共用注射器具方式及性行为同HCV感染的关系及其联系强度。 |
| 英文摘要: |
| Objective To study hepatitis C virus (HCV) transmission through different modes of sharing injection equipment and sexual behavior among injecting drug users (IDUs) in Liangshan of Sichuan province. Methods A community-based survey was conducted to investigate past and current demographic data,injection equipment sharing patterns and sexual behavior of IDUs. Blood samples were also taken to test for HCV. The survey was conducted between Nov 8 and Nov 29,2002. 379 subjects were screened through outreach recruitment and peer informing. SPSS(11.5) was used for data analysis. Results HCV prevalence was 71.0%(269/379). Needles or syringes sharing in the past three months and past syphilis infection were strongly associaled with HCV transmission after univariate analysis using chi-square test. Trend analysis indicated that HCV infection rate increased along with the increase of needles or syringes sharing,sharing of rinse water and the number of peers sharing the equipments. Data from multivariate logistic regression showed that sharing of needles or syringes and history of syphilis infection were significantly associated with HCV transmission. No significant difference was found between HCV infection and sexual behavior after univariate analysis using chi-square test. ConclusionFurther sero-epidemiological prospective cohort studies should be conducted to clarify the relationship between different modes of sharing injection equipment, sexual behavior and HCV infection. |
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