文章摘要
郜艳晖,姜庆五,周学富,丁保国,王如鸿,赵根明.一种病例对照家系资料的家庭相关统计分析方法[J].中华流行病学杂志,2004,25(11):992-996
一种病例对照家系资料的家庭相关统计分析方法
A new statistical method on familial correlation dealing with family data from case-control studies
收稿日期:2004-04-26  出版日期:2014-09-17
DOI:
中文关键词: 病例对照家系设计  家庭相关  广义估计方程
英文关键词: Case-control family study  Familial correlation  Generalized estimating equations
基金项目:国家自然科学基金(39930160)
作者单位
郜艳晖 复旦大学公共卫生学院流行病学教研室, 200032 
姜庆五 复旦大学公共卫生学院流行病学教研室, 200032 
周学富 江苏省泰兴市疾病预防控制中心 
丁保国 江苏省泰兴市疾病预防控制中心 
王如鸿 江苏省泰兴市疾病预防控制中心 
赵根明 复旦大学公共卫生学院流行病学教研室, 200032 
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中文摘要:
      目的 提出一种分析病例对照家系资料家庭相关的统计方法。方法 同时建立先证者疾病状态和给定先证者疾病状态条件下亲属疾病状态的边际均数回归模型和亲属的边际关联回归模型,联合条件OR值和边际OR值评价家庭相关。结果 该模型参数解释符合抽样设计的特点,在评价危险因素作用上能充分利用信息,因此有较高效能。此外,该法具有GEE2方法估计家庭相关的所有其他优点。结论 该法用于病例对照家系资料估计疾病的家庭相关,简单、方便、有效。
英文摘要:
      Objective This paper presents a statistical method of familial correlation on family data from case-control studies. Methods Marginal mean models of the probands and the relatives conditional on the proband's disease status, as well as the marginal association model of the relatives were modeled integrately. Conditional odds-ratio and marginal odds-ratio were used to measure the familial correlation. Results The parameter's interpretation in the model was in accordance with sample characteristics. This method is more efficient due to making fully use of information of the probands and relatives. In addition, the method has all advantages of GEE2. Conclusion The method in this paper efficiently and conveniently analyzes the family data from case-control studies to estimate the familial correlation on disease.
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