文章摘要
周艺彪,姜庆五,赵根明.化疗控制人群感染日本血吸虫的效果分析[J].中华流行病学杂志,2004,25(12):1024-1027
化疗控制人群感染日本血吸虫的效果分析
Effect of chemotherapy on the contml of schistomiis。
收稿日期:2004-04-26  出版日期:2014-09-17
DOI:
中文关键词: 血吸虫病,日本;选择性化疗;感染率;感染度
英文关键词: Schistosomiasis, ]anicum;Selective chemotherapy;Infection rate;-Intensity of infection
基金项目:
作者单位
周艺彪 复旦大学公共卫生学院流行病学教研室, 上海 200032 
姜庆五 复旦大学公共卫生学院流行病学教研室, 上海 200032 
赵根明 复旦大学公共卫生学院流行病学教研室, 上海 200032 
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中文摘要:
      目的 探讨以选择性化疗为主的防制措施控制日本血吸虫病感染的效果。方法利用2000-2002年全国血吸虫病监测点资料,采用Meta分析中的随机效应模型分析化疗控制日本血吸虫感染的效果。结果经化疗后1年,居民感染率在10%以上的观察村,居民血吸虫感染率、患者和人群感染度均明显下降,分别下降20.15%、22.91%和33.93%,其95%的可信区间(CI)分别为6.95-31.48、14.69-30 34和11.69-50.68 居民感染率在6%-10%之间的观察村,化疗仍可以明显降低血吸虫感染率,下降了24.50%,其95%CI为5.35-39.83,但感染率< 6%的观察村,感染率不再明显下降 患者和人群感染度在居民感染率≤10%的观察村,均维持在原有的水平。结论 以选择性化疗为主的防制措施仍能有效降低中国血吸虫病的病情,并将其控制在一个较低的水平,但很难达到阻断血吸虫病的目的。
英文摘要:
      Objective To study the effect of infection control on schistosomasisp“based on selective chotherapy. Methods Data were derived from national surveillance of schistosomiasis from 2000 to 2002,and random effect model of Meta—analysis was used to analyze the effect of chemotherapy on contmlling schistosomiasis infection.Results One year after chemotherapy waS started in the pilot villages where infection rate of schistosomiaSis was more than 10%,the infection rates among residents and rgs per gm(EPG)of patients as well as population(geOmetric mean,GM)significantly reduced by 20.15%,22.91%and 33.93%with 95%confidence inteⅣal(CJ)6.95—31.48,14.69—30.34 and 11.69—50.68respectively. In the pilot vmages where infection rates were between 6%and 10%,the control measures IargeIy base on chemotherapy significantIy reduced the infection rate,by 24.50(95%Cf:5.35—39.83).However the infection rates were no longer reduced in the pilot villages where the infection rate was less than 6%;EPG of patients and residents were maintained at the original level in the pilot viUages where infection rate was 10%or leSS.Conclusions In China,the rates of schistos(mliasis.kic“7infection could be effectively reduced through the control measures 1argely based on chemotherapy, and they were kept at a relatively low 1evel.However,it was very difficult to interrupt the transmiSsion of schistosomiaSis.
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