| 胡志斌,缪小平,马红霞,谭文,钮菊英,林东昕,沈洪兵.肺癌易感性与p73基因多态性关系的研究[J].中华流行病学杂志,2005,26(2):106-109 |
| 肺癌易感性与p73基因多态性关系的研究 |
| Association of two genetic polymorphisms in the 5' untranslated region of exon 2 of the p73 gene and risk of lung cancer |
| 收稿日期:2004-06-10 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 肺肿瘤 p73基因 流行病学 分子 |
| 英文关键词: Lung neoplasms p73 gene Epidemiology molecular |
| 基金项目:国家“973”重大基础研究基金资助项目(2002CB512902);国家自然科学基金资助项目(30371240) |
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| 中文摘要: |
| 目的 探讨中国人群p73基因 5'UTR区域两个单核苷酸多态性 (G4C14,A4T14 )与肺癌的关系。方法 采用病例对照研究;选择经组织学确诊的肺癌病例 4 2 5例,地区、年龄和性别频数匹配的对照 5 88名,以聚合酶链反应 单链构象多态性方法进行多态性检测。结果 此两个多态性之间具备完全的连锁不平衡,AT(A4T14 )单倍型在病例组显著少于对照组 (0 .2 2 5vs.0 .2 87,P =0 .0 0 18),提示变异的AT单倍型对肺癌具有保护作用。与携带p73GC GC单倍型基因型者比较,携带GC AT单倍型基因型者肺癌风险降低 30 % (OR =0 .70,95 %CI:0 .5 3～ 0 .92 ),而携带AT AT单倍型基因型者肺癌风险降低 5 5 % (OR =0 .70,95 %CI:0 .2 6～ 0 .80 )。结论 p73基因多态改变可能与中国汉族人群肺癌遗传易感性有关。 |
| 英文摘要: |
| Objective To study the relationship between two potential functional polymorphisms in exon 2 of the p73 gene and the susceptibility of lung cancer. Methods Genotypes were determined by polymerase chain reaction-single stand conformation polymorphism(PCR-SSCP) method in 425 histologically-confirmed lung cancer cases and 588 cancer-free controls, frequency-matched by age and sex. Results The two polymorphisms were in complete linkage disequilibrium and the frequencies of variant p73 AT haplotype (A4T14) were less commonly seen in the cases ( 0.225 ) than in the controls ( 0.287 ) ( P = 0.0018 ). Compared with the p73 GC/GC homozygotes,both the AT/AT variant homozygotes and GC/AT heterozygotes were associated with a significantly decreased risk [adjusted odds ratio ( OR )= 0.45,95% confidence interval ( CI )= 0.26- 0.80 and OR = 0.70,95% CI = 0.53- 0.92,respectively]. Conclusion These results suggested that this p73 dinucleotide polymorphism might have had a role to play in the susceptibility of lung cancer. |
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