| 段琼红,王志刚,朱桂宝,卢祖洵,施侣元,聂绍发.血清IGF-1、IGFBP-3水平和大肠癌关系的Meta分析[J].中华流行病学杂志,2005,26(2):132-134 |
| 血清IGF-1、IGFBP-3水平和大肠癌关系的Meta分析 |
| Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis |
| 收稿日期:2004-05-26 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 肿瘤,结直肠 胰岛素样生长因子 胰岛素样生长因子结合蛋白 Meta分析 |
| 英文关键词: Colorectal cancer Insulin-like growth factors Insulin-like growth factor binding protein Meta-analysis |
| 基金项目:国家自然科学基金资助项目(30371239) |
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| 中文摘要: |
| 目的 综合评价血清胰岛素样生长因子 1(IGF- 1)、胰岛素样生长因子结合蛋白 3(IGFBP -3)水平和大肠癌的关系。方法 利用Meta分析法对 6篇关于血清IGF- 1、IGFBP- 3水平与大肠癌关系的研究文献进行定量综合分析。结果 对于IGF 1,合并OR =1.5 6 (95 %CI:1.14～ 2 .13);按实验方法不同分层,间接酶联免疫吸附试验 (ELISA)合并OR =1.92 (95 %CI:1.2 6～ 2 .93),IRMA法合并OR =1.2 3(95 %CI:0 .78～ 1.94 );对于IGFBP 3,合并OR =0 .78(95 %CI:0 .4 3～ 1.4 4 );按实验方法不同分层,ELISA法合并OR =0 .4 6 (95 %CI:0 .2 9～ 0 .74 ),免疫放射测定法 (IRMA)合并OR =1.4 4 (95 %CI:0 .93～ 2 .2 3)。结论 血清IGF -1高水平为大肠癌的独立危险因子,IGFBP- 3与大肠癌的关联不具有统计学意义;IGFBP -3与大肠癌关系的各研究之间异质性是由实验方法不同而引起,但该结论尚需大样本并同时进行两种方法的测量证实。 |
| 英文摘要: |
| Objective To evaluate the relationship between circulating levels of insulin-like growth factor-1(IGF-1),IGF-binding protein-3(IGFBP-3) and colorectal cancer. Methods A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed. Results The pooled odds ratio( OR ) of IGF-1 and IGFBP-3 were 1.56 (95% CI : 1.14- 2.13 ) and 0.78 (95% CI : 0.43- 1.44 ) respectively. According to the results from different measurements(enzyme-linked immunoabsorbent assay and immunoradiometric assay),the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively. Conclusion High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used,but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion. |
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