文章摘要
王金桃,高尔生,程玉英,闫建文,丁玲.内源性雌、孕激素与人乳头瘤病毒在宫颈癌发生中的协同作用研究[J].中华流行病学杂志,2005,26(5):370-373
内源性雌、孕激素与人乳头瘤病毒在宫颈癌发生中的协同作用研究
Analysis on synergistic action between estrogen,progesterone and human papillomaviruses in cervical cancer
收稿日期:2004-08-06  出版日期:2014-09-15
DOI:
中文关键词: 宫颈癌;人乳头瘤病毒;内源性雌激素;协同作用
英文关键词: Cervical cancer;Human papillomaviruses;Entogenous estrogen;Synergistic action
基金项目:山西省科技攻关课题资助项目(021080)
作者单位
王金桃 山西医科大学流行病学教研室 太原 030001 
高尔生 上海市计划生育科研所 
程玉英 山西省肿瘤医院 
闫建文 山西省肿瘤医院 
丁玲 山西医科大学流行病学教研室 太原 030001 
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中文摘要:
      目的 探讨雌、孕激素对宫颈癌发生的作用及其与人乳头瘤病毒(HPV)的协同作用. 方法 采用热启动PCR和ELISA法, 对141例宫颈癌和129名健康妇女进行了HPVs、HPV16、雌二醇(E2)和孕酮(P)含量的测定. 结果 宫颈癌组HPVs和HPV16的阳性率分别为75. 2%和46. 8%, 显著高于健康对照组;血清中E2和P的平均浓度均为病例组高于对照组, 差异有统计学意义, 特别是E2水平与宫颈癌之间呈剂量反应关系;E2与HPVs之间呈正相加交互作用, 且有统计学意义. 结论 HPV感染, 特别是HPV16感染在宫颈癌发生中起重要作用;内源性雌激素的升高可增加宫颈癌发生的危险性;高水平的雌二醇和HPV感染对宫颈癌的发生可能具有协同作用.
英文摘要:
      Objective To explore the effects of estrogen (E_2)and progesterone (P)on cervical cancer and the synergistic action between estrogen,progesterone and human papillomaviruses (HPV). Methods Hoted-start polymerase chain reaction (HS-PCR)was used to detect HPVs, HPV16 and ELISA was used to assay E_2 and P on 141 cases with cervical cancer and on 129 healthy controls. Results Positive rates of HPVs and HPV16 were 75.2 % and 46.8 % respectively in cervical cancer group, significantly higher than that in controls. Levels of estrogen and progesterone in case group were significantly higher than that in controls and a dose-responded relationship between the levels of estrogen and cervical cancer was revealed. Estrogen and HPV showed an additive interaction in the development of cervical cancer. Conclusion HPV16 infection played a principal role in the development of cervical cancer. The high levels of entogenous estrogen could increase the risk of cervical cancer and might serve as a cofactor in the development of HPV-induced cervical cancer.
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