文章摘要
屈秋民,乔晋,韩建峰,杨剑波,郭峰,罗国刚,杨华,曹红梅,俱西驰,武成斌.陕西省西安地区中老年人痴呆及其主要亚型发病率调查[J].中华流行病学杂志,2005,26(7):529-532
陕西省西安地区中老年人痴呆及其主要亚型发病率调查
The incidence of dementia among elderly people in Xi'an, China
收稿日期:2004-10-14  出版日期:2014-09-15
DOI:
中文关键词: 痴呆;Alzheimer病;血管性痴呆;发病率;危险因素
英文关键词: Dementia;Alzheimer disease;V ascular dementia;Incidence;Risk factor
基金项目:中华医学基金会资助项目(96-906)
作者单位
屈秋民 西安交通大学医学院第一附属医院神经内科, 710061 
乔晋 西安交通大学医学院第一附属医院神经内科, 710061 
韩建峰 西安交通大学医学院第一附属医院神经内科, 710061 
杨剑波 西安交通大学医学院第一附属医院神经内科, 710061 
郭峰 西安交通大学医学院第一附属医院神经内科, 710061 
罗国刚 西安交通大学医学院第一附属医院神经内科, 710061 
杨华 西安交通大学医学院第一附属医院神经内科, 710061 
曹红梅 西安交通大学医学院第一附属医院神经内科, 710061 
俱西驰 西安交通大学医学院第一附属医院神经内科, 710061 
武成斌 西安交通大学医学院第一附属医院神经内科, 710061 
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中文摘要:
      目的 了解西安地区中老年人痴呆及其主要亚型的发病率,分析痴呆及其主要亚型的危险因素。方法 对1998年完成痴呆患病率调查的2919名西安地区居民进行随访,以简易智能量表(MMSE)作为筛查工具,应用三阶段诊断法确诊痴呆及其亚型。根据随访的人年数计算痴呆、Alzheimer病(AD)及血管性痴呆(VD)的年发病率。痴呆诊断按照美国精神疾病诊断、统计手册第三版(修订版)(DSM-Ⅲ-R)的标准,AD诊断按照美国国立神经疾病、语言交流障碍和卒中-老年性痴呆及相关疾病学会(NINCDS-ADRDA)的标准,VD诊断按照美国国立神经疾病和卒中研究所和瑞士国际神经科学研究协会(NINDS-AIREN)标准的。结果实际随访到2197人,平均随访3.2年,共计6886.43人年。新诊断痴呆47例,其中AD37例,VD8例,其他原因引起的痴呆2例。55岁以上人群痴呆及AD、VD年发病率分别为0.68%、0.54%、0.12%;65岁以上人群痴呆及AD、VD年发病率分别为0.89%、0.69%、0.17%。单因素分析和多因素logistic回归分析显示,AD发病率与年龄、文化程度密切相关;而VD发病率与年龄、卒中史和高血压密切相关。结论 高龄、低文化程度是AD的危险因素,而年龄、高血压和卒中是VD的危险因素。
英文摘要:
      Objective To explore the incidence of dementia among elderly people in Xi'an and its related risk factors. Methods Subjects that had been studied on the prevalence of dementia were follow up, and the incidence of dementia, Alzheimer disease(AD), and vascular dementia(VD) were counted by person-years. The clinical diagnosis on dementia, AD and VD were based upon the 3rd Edition of Diagnostic and Statistical of Manual of Mental Disorder, Revised version(DSM-Ⅲ-R) and NINCDS-ADRDA criteria. Results 2197 subjects of non-dementia being identified in 1998, were re-surveyed in 2001. Out of them, 47 new cases of dementia including 37 cases of AD and 8 cases of VD were identified, with an annual incidence rates of dementia, AD and VD as 0.68%, 0.54% and 0.12% among those of 55 years and overand 0.89%, 0.69% and 0.17% in 65 years and over, respectively. Analysis from single factor logistic regression showed that age and education but not gender were closely related to the occurrence of AD. On the contrary, age, hypertension and stroke were closely related to the occurrence of VD. ConclusionThe incidence of dementia in the "Xi'an cohort" was similar to that being reported from other countries. AD and VD were an age related diseases but education seemed to have had great protective effect while lack of formal education served as risk factor to AD.
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