文章摘要
宣世英,辛永宁,陈桦,史光军,孙樱,张健.肝癌组织、癌旁组织中HBsAg、HCV抗原表达与肝组织纤维化分期的相关性研究[J].中华流行病学杂志,2006,27(2):157-160
肝癌组织、癌旁组织中HBsAg、HCV抗原表达与肝组织纤维化分期的相关性研究
Study on the correlations between HBsAg and hepatitis C virus expression as well as fibrotic staging in hepatocellular carcinoma and pericarcinomatous tissues
投稿时间:2005-01-24  
DOI:
中文关键词: 乙型肝炎表面抗原;丙型肝炎抗原;肝纤维化分期;免疫组织化学;肝细胞瘤
英文关键词: Hepatitis B virus surface antigen;Hepatitis Cvirus antigen;Fibrotic staging;Immunohistochemistry;Hepatocellular carcinoma
基金项目:
作者单位
宣世英 266011 青岛市市立医院肝病科 
辛永宁 266011 青岛市市立医院肝病科 
陈桦 青岛市市立医院病理科 
史光军 青岛市市立医院肝胆外科 
孙樱 266011 青岛市市立医院肝病科 
张健 266011 青岛市市立医院肝病科 
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中文摘要:
      目的研究肝癌组织、癌旁组织中乙型肝炎表面抗原(HBsAg)、丙型肝炎病毒(HCV)抗原表达与肝组织纤维化分期的相关性。方法采用免疫组织化学方法对肝癌组织及癌旁组织中的HBsAg、HCV抗原表达进行了标记和分析,同时对肝癌组织及癌旁组织进行肝组织纤维化分期。结果肝组织纤维化程度与HBV、HCV感染有明显相关(rs=0.32,P=0.001);HBsAg和HCV抗原在癌组织及癌旁组织中表达有差异,HBsAg主要在癌旁组织表达(79%),高于癌组织(23%);而HCV抗原在癌组织(15%)与癌旁组织表达(23%)水平相当。结论有病毒感染背景的肝癌组织,其纤维化程度高于无病毒感染的肝癌组织;病毒的感染是肝癌发生的原因,长期的病毒血症会加速肝纤维化的进展。
英文摘要:
      Objective To study the co rrelation between hepatitis B virus surface antigen (HBsAg) and hepatitis C vir us(HCV) expression as w ell as fibrosis staging in hepatocellular carcinoma(HCC) and pericar cinomatous tissues. Methods The patterns o f HBsAg and HCV in 100 cases of HCC and their surrounding liv er tissues were studied on par affin- embeded sect ions with immunohistochemistr y technique, and liver tissues were also staged. Results HBV, HCV virus infection w ere positively correlated w ith the fibrotic stag ing (rs =0. 32, P=0. 001 ). HBsAg and HCV were detected both in HCC and pericar cinomatous tissues. The positive r ate of HBsAg in Pericarcinomatous Tissues(79%) was higher than that of in HCC tissues(23%). HCV ex pressions in HCC (15%) and pericarcinomatous tissues (23%) show ed no sig nificant differences. Conclusion The fibrotic degree in the tissues of liver cancer with previous virus infection was obviously higher t han that without virus infection。Viral infectio n seemed to be one of the reasons causing liver cancer while perennial virusemia would aggravate pathological changes of the liver tissue.
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