文章摘要
易洪刚,陈峰,于浩,赵杨,娄东华.病例同胞对照设计[J].中华流行病学杂志,2006,27(2):170-173
病例同胞对照设计
Introduction on“case-sibling control design”
投稿时间:2005-09-08  
DOI:
中文关键词: 病例同胞对照设计;关联;连锁;基因
英文关键词: Case2sibling control design;Association;Linkage;Gene
基金项目:国家重点基础研究发展计划(973)资助项目(2002CB512910);国家自然科学基金资助项目(30571619);江苏省高校自然科学基金重点项目资助(04KJB310081)
作者单位E-mail
易洪刚 210029 南京医科大学公共卫生学院流行病与卫生统计学系  
陈峰 210029 南京医科大学公共卫生学院流行病与卫生统计学系 ohcepf@163.com 
于浩 210029 南京医科大学公共卫生学院流行病与卫生统计学系  
赵杨 210029 南京医科大学公共卫生学院流行病与卫生统计学系  
娄东华 210029 南京医科大学公共卫生学院流行病与卫生统计学系  
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中文摘要:
      目的介绍病例同胞对照设计的研究设计及统计分析方法,并对实际资料进行统计分析。方法以亚甲基四氢叶酸还原酶基因C677T突变与冠心病连锁研究为实例,采用同胞-传递不平衡检验(s-TDT)和同胞组不平衡检验(SDT)等方法进行统计分析。结果采用s-TDT分析,统计量Z=0.27,P>0.05;采用SDT分析,χ2=0.31,P>0.05。提示受累子代与非受累子代T等位基因分布差异无统计学意义。结论病例同胞对照设计使用患者同胞作为对照,避免了人群分层现象,可以用来检测基因与疾病之间的关联或连锁。
英文摘要:
      Objective To introduce the design and statistical methods of case2sibling control design and to analyze the published data. Methods Data from an association study between the coronary heart disease and methylenetetrahydrofolate reductase gene C677T polymorphism was analyzed by the sib transmissionPdisequibrium test (s2TDT) and the sibship disequilibrium (SDT) methods. Results Using s2TDT method, Z value was 0. 27 with P > 0. 05. The result of SDT method showed that chi2square was 0. 31 with 1 df, P > 0. 05. All results suggested that neither s2TDT nor SDT showed significant difference between the transmitted and untransmitted methylenetetrahydrofolate reductase gene C677T allele distributions. Conclusion Case-sibling control design might avoid population stratification by using siblings as controls thus might be used to test association and linkage between genes and disease
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