文章摘要
王金桃,马晓晨,程玉英,丁玲,周芩.叶酸与宫颈癌关系的病例对照研究[J].中华流行病学杂志,2006,27(5):424-427
叶酸与宫颈癌关系的病例对照研究
A case-control study on the associatlou between folate and cervical cancer
收稿日期:2005-08-25  出版日期:2014-09-12
DOI:
中文关键词: 宫颈肿瘤  叶酸  人乳头瘤病毒  病例对照研究
英文关键词: Cervical neoplasms  Folate  Human papillomaviruses  Case-mntrol study
基金项目:山西省科技攻关课题资助项目(021080)
作者单位
王金桃 山西医科大学流行病学教研室, 太原 030001 
马晓晨 山西医科大学流行病学教研室, 太原 030001 
程玉英 山西医科大学流行病学教研室, 太原 030001 
丁玲 北京市疾病预防控制中心 
周芩 山西省肿瘤医院 
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中文摘要:
      目的探讨膳食叶酸、血清叶酸与宫颈癌的关系以及叶酸和人乳头瘤病毒(HPV)16在宫颈癌发生中的相互作用。方法采用以医院为基础的病例对照研究方法,对111例经病理学确诊的宫颈鳞癌新发病例和111例子宫肌瘤患者进行年龄、籍贯、居住地匹配,在收集宫颈癌相关因素的同时,采用食物频数问卷(FFQ)调查膳食叶酸摄入情况,利用特异PCR检测HPV16 DNA,血清叶酸采用RIA定量测定。结果官颈癌组HPV16感染率(61.26%)显著高于对照组(28.83%),调整OR 值4.95(95%CI:2.49-9.83);病例组膳食叶酸摄入量(5.00μg/kcal±0.41 μg/kcal)和血清叶酸水平 (1.79 ng/ml±1.42 ng/ml)均低于对照组(5.14μg/kcal±0.35μg/kcal,2.59 ng/ml±2.81 ng/ml),差异有统计学意义,特别是随着血清叶酸水平的降低,患宫颈癌的危险性增加(X2=17.37,P=0.000);血清叶酸水平较低同时伴有HPV16感染患宫颈癌的危险明显高于两者单独作用之和,交互作用检验有统计学意义(G=5.56,P=0.02)。结论叶酸缺乏可增加宫颈癌发生的危险。
英文摘要:
      Objective To evaluate the possible effects of folate on cervical carcinogenesis and the interaction of folate and human papillomaviruses 16(HPV16).Methods A hospital-based case-control study was conducted. 11 I hospitalized cases who were pathologically diagnosed of having cervical cancer and 111 controls identified with hysteromyoma that frequency-matched to cases on age, birth place and residential area. A 60-item food-frequency questionnaire(FFQ)were administered to estimate the consumption of dietary folate. HPV16 DNA in exfoliated cervical cell and serum folate were detected by special PCR and radioimmunoassay respectively. Results HPV16 infection rate in cases ( 61.26 %)was significantly higher than that in controls(28.83%),with adjusted OR of 4.95(95%CI:2.49-9.83).The levels of dietary folate in cases (5.00 ug/kcal10.41 ug/kcal) were significantly lower than that in controls (5.14 pg/kcal士0.35 ug/kcal),but the adjusted OR showing no statistical significance. However, serum folate in cases(1.79 ng/ml 1 1.42 ng/ml) was significantly lower than that in controls(2.59 ng/ml士2.81ng/ml),and there were significantly increasing trend in the risk of cervical cancer with reducing level of serum folate ( x2R}:二of P=0.000).Meanwhile, low-level of serum folate and HPV16-infection showed significant interaction in the development of cervical cancer, with likelihood ratio test of G=5.56,P=0.02.Conclusion Results indicated that low levels of folate might increase the risk of cervical cancer,and potential synergistic action might exist between low level of serum folate and HPV16 in the development of cervical cancer.
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