| 张玉琦,袁国桢,李桂林,姚建军,程灶火,储兴,刘朝军,刘庆海,王爱荣,史桂芝,王宝恒,成义仁,张明廉,李克.215例抑郁症患者自杀未遂危险因素的配对病例对照研究[J].中华流行病学杂志,2007,28(2):131-135 |
| 215例抑郁症患者自杀未遂危险因素的配对病例对照研究 |
| A case-control study on the risk factors for attempted suicide in patients with major depression |
| 收稿日期:2006-04-20 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 抑郁症 自杀未遂 色氨酸羟化酶基因 单核苷酸多态性 病例对照研究 |
| 英文关键词: Major depression Suicidal attempt TPH2 gene Single nucleotide polymorphism Case-control study |
| 基金项目:江苏省“333工程”基金资助项目 |
| 作者 | 单位 | | 张玉琦 | 南京医科大学附属无锡精神卫生中心精神科, 无锡 214151 | | 袁国桢 | 南京医科大学附属无锡精神卫生中心精神科, 无锡 214151 | | 李桂林 | 南京医科大学附属无锡精神卫生中心精神科, 无锡 214151 | | 姚建军 | 南京医科大学附属无锡精神卫生中心精神科, 无锡 214151 | | 程灶火 | 南京医科大学附属无锡精神卫生中心精神科, 无锡 214151 | | 储兴 | 南京医科大学附属无锡精神卫生中心精神科, 无锡 214151 | | 刘朝军 | 山东省安康医院精神科, 济宁 272100 | | 刘庆海 | 山东省安康医院精神科, 济宁 272100 | | 王爱荣 | 山东省安康医院精神科, 济宁 272100 | | 史桂芝 | 汕头大学医学院分子遗传学教研室, 汕头 515063 | | 王宝恒 | 汕头大学医学院分子遗传学教研室, 汕头 515063 | | 成义仁 | 山东省安康医院精神科, 济宁 272100 | | 张明廉 | 南京医科大学附属无锡精神卫生中心精神科, 无锡 214151 | | 李克 | 汕头大学医学院分子遗传学教研室, 汕头 515063 |
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| 中文摘要: |
| 目的: 了解汉族人群抑郁症患者自杀未遂的环境危险因素、色氨酸羟化酶2(TPH2)基因rs7305115单核苷酸多态性与自杀未遂有无关联。方法: 采用配对病例对照研究, 对215例自杀未遂者(男性92例、女性123例)与相应对照(与病例同性别、年龄相差3岁以内、同地区)进行TPH2 rs7305115基因型测定、自杀行为干预研究量表调查环境因素与抑郁症自杀未遂的关系研究。结果: 研究组与对照组在TPI-L2 rs7305115基因型、基因频率的差异有统计学意义(P<0.001); 多因素条件 logistic回归模型分析显示, 绝望、负性生活事件、有自杀家族史, 均为抑郁症自杀未遂危险因素, OR值分别为7.68(95%CI:5.79～13.74)、6.64(95%Cj:2.48～11,04)、2.98(95%CI:1.17～5.04); TPH2 rs7305115 A/A为抑郁症自杀未遂的保护因素0.33(95%CI:0.22～0.99)。结论: 绝望、负性生活事件、自杀家族史是抑郁症自杀未遂的危险因素, TPH2 rs7305115 A/A可能是抑郁症自杀行为的保护因素。 |
| 英文摘要: |
| 0bjective: To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism (SNP) of TPH2 gene rs7305115 associated to attempted suicide in major depression. Methods: Paired case-control study on 215 suicide attempters with major depression(92 male, 123 female) and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP.interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender similar age (no more than 3 years) and from the same district. Results: There were remarkably significant differences in gene types and gene frequency between case and control groups (P<0.001). Data from multivariate conditional logistic regression model analysis showed that hopelessness,negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 ( 95% CI:0.22.0.99), 7.68 ( 95% CI:5.79-13.74), 6.64( 95% CI:2.48 11.04), 2.98 ( 95% CI: 1.17-5.04) respectively. There was no first level interaetion between any of the two risk factors. Conclusion: Results from the study supported the idea that hopelessness. negative life-events and fanfily history of suicide were risk factors of attempted suicide in major depression while TPH2 geners7305115 A/A might be the protective factor. |
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