| 王华庆,郭欣,陈丽娟,杨洁,和京果,罗明,贺雄,周玉清,曹玲生,卢永,殷大鹏,陈园生,夏伟,梁晓峰.深圳地区生态环境中非结核分枝杆菌分布状况调查[J].中华流行病学杂志,2007,28(5):433-436 |
| 深圳地区生态环境中非结核分枝杆菌分布状况调查 |
| An epidemiological study on the ecological environment related to Nontuberculous mycobacteria in Shenzhen city of Guangdong province |
| 收稿日期:2006-06-30 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 非结核分枝杆菌 环境 鉴定 药物敏感试验 |
| 英文关键词: Diphtheria Vaccine Coverage rate Children |
| 基金项目: |
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| 中文摘要: |
| 目的 调查广东省深圳地区生态环境中非结核分枝杆菌(NTM)分布及其药敏情况。方法 对采集到的145份环境样品按《结核病诊断实验室检验规程》进行NTM分离培养、鉴定和药敏试验。结果 145份样品中共检出NTM 53株，其中医院处理前地下污水检出6株，处理后地下污水检出4株;医院空调过滤网灰尘检出4株;居民生活污水检出34株;海水检出3株;人工喷泉水检出2株;检出的细菌有:无色分枝杆菌、鸟分枝杆菌、偶发分枝杆菌、戈登分枝杆菌、日内瓦分枝杆菌、龟分枝杆菌和胞内分枝杆菌。结论 NTM在深圳市自然环境中普遍存在，且对抗结核药物有较高耐药性。 |
| 英文摘要: |
| Objective To investigate the immunity level of diphtheria antibody among children living in the areas where different coverage rates of 4-vaccines stratified by Results of national immunization program (NIP)reviewed in 2004. Methods According to data from 4-vaccine coverage rates of NIP reviewed in 2004, 3 levels could be set. We randomly selected 2 counties at each level and then 10 villages from each county with 42 children involved who were bom between 1992 and 2003. ELISA quantitative method was used to test IgG of diphtheria antitoxin. Results (1) The p}itive rate of diphtheria antitoxin was only 49.60% with the highest as 78.1%and lowest as 33. 0 %.There was a significant decreasing trend of this positive rate with the increase of age. The highest(61. 2 %)fell in the group that were bom in 2003 and the lowest(37.6%)was seen among children bom in 1992 to 1995. (2)Geometric~concentrations(GMCs) was only 0. 48 IU/ml with a trend of decrease when age was increasing. There was no GMCs peak seen in children who were at the age of boosting, as expected. ( 3 )Positive rates of children bom between 2001 and 2003 were lower than 62 % while the diphtheria-pertussis-tetanus(DPT) vaccine coverage rates were all higher than 90%. (4)There was no significant difference of diphtheria antitoxin positive rates between children with eligible routine immunization( 58.1%) and those were ineligible (59.6%).Conclusion Other than~specific ones,children from most of the investigated counties had a low level of antibody against diphtheria. The coverage rate of DPT vaccine did not necessarily reflect the immunity against diphtheria,suggesting the increase of immunity against diphtheria an urgent task to be taken care of. |
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