181例艾滋病患者高效抗逆转录病毒治疗效果评价

许奕华; 廖巧红; 王重建; 刘建平; 向浩; 冉鹏; 何卫华; 张晓东; 金小舟; 聂绍发

文章摘要

许奕华,廖巧红,王重建,刘建平,向浩,冉鹏,何卫华,张晓东,金小舟,聂绍发.181例艾滋病患者高效抗逆转录病毒治疗效果评价[J].中华流行病学杂志,2007,28(7):704-707

181例艾滋病患者高效抗逆转录病毒治疗效果评价

Evaluation on the highly active anti-retroviral therapy in 181 AIDS patients

收稿日期:2006-12-15 出版日期:2014-09-18

DOI：

中文关键词: 艾滋病高效抗逆转录病毒治疗临床依从性

英文关键词: AIDS Highly active anti-retroviral therapy Clinical compliance

基金项目:中英艾滋病策略支持项目(19513028)

作者	单位	E-mail
许奕华	华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030	sf_nie@mails.tjmu.edu.cn
廖巧红	华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
王重建	华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
刘建平	华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
向浩	华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
冉鹏	华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
何卫华	湖北省随州市疾病预防控制中心
张晓东	湖北省随州市疾病预防控制中心
金小舟	湖北省随州市疾病预防控制中心
聂绍发	华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030

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中文摘要:

目的探讨艾滋病患者经高效抗逆转录病毒疗法(HAART)治疗后所取得的临床效果.方法采用流行病学描述性研究的方法,从5个纬度对湖北省随州市181例艾滋病患者治疗后临床症状、79例病毒载量和免疫功能的改变情况进行描述,用Epi Data双人录入数据,SPSS 13.0软件建立数据库,并进行统计学分析.结果对不规则发热、咳嗽、腹泻、淋巴结肿大、体质量下降、皮疹、真菌感染有效率分别为81.39%、85.00%、84.62%、81.89%、82.86%、66.07%和45.45%.用药后CD4+T淋巴细胞计数明显升高,3个月CD4+T淋巴细胞计数平均为276×106/ml(65×106/ml～824×106/ml),上升129×106/ml.6个月CD4+T淋巴细胞计数平均为294×106/ml(102×106/ml～750×106/ml).用药后6个月与3个月相比较无明显变化.停药者中死亡人数14例,病死率29 79%;未停药者死亡人数3例,病死率2.24%.结论 HAART治疗可明显改善艾滋病患者的临床症状,有效降低病毒载量,提高临床依从性可降低病死率.

英文摘要:

Objective To study the clinical effect under highly active anti-retroviral therapy (HAART) in AIDS patients and for improving the curative effect and prognosis.Methods Epidemiological method was used from five aspects to describe the post-treatment clinical symptoms of 181 AIDS patients in Suizhou,and to evaluate the change of virus load and immune function of 79 AIDS patients.Data was doubly recorded by Epi Data and database was set up by SPSS 13.0 for analysis.Results The effective powers of anomal-fever,cough,diarrhoea,lymphadenectasis,weight drop,erythra, mycotic infection were 81.39%,85.00%,84.62%,81.89%,82.86%,66.07% and 45.45% respectively.CD4~+ Tlymphocyte count rose obviously after treatment,with an averag of 276× 10~6 cells/ml (65× 10~6-824× 10~6 cells/ml),an 129× 10~6 cells/ml increase in three months and was 294× 10~6 cells/ml (102× 10~6-750× 10~6 cells/ml) in six months.The count change of CD4~+ T lymphocyte between 3 months and 6 months did not show sigificant difference.The number of deaths among drug withdrawals was 14, with a case fatality rate as 29.79%;while the number of deaths among non-drug withdrawals was 3,with the case fatality rate as 2.24%.Conclusion Results through this study showed that HAART could obviously improve the clinical symptom of AIDS patients,and to increase the number of virus load. Improving the compliance could also reduce the case fatality rate.

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