| 褚小刚,张险峰,詹发先,汤恒,陈慧萍,彭庭海,龚作炯.湖北省HIV-1分子流行病学研究[J].中华流行病学杂志,2007,28(10):992-995 |
| 湖北省HIV-1分子流行病学研究 |
| Study on molecular epidemiology of people infected with human immunodeficiency virus-1 in Hubei province |
| 收稿日期:2007-01-29 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 艾滋病 人免疫缺陷病毒1型 流行病学,分子 |
| 英文关键词: Acquired immunedeficiency syndrom Human immunodeficiency virus-1 Epidemiology, molecular |
| 基金项目:湖北省卫生厅科研基金重点项目(JX2A17;JX3A23) |
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| 中文摘要: |
| 目的 了解湖北省HIV-1基因型分布特征。方法 对湖北省HIV-I主要流行区域进行流行病学调查，应用巢式聚合酶链反应对其中102例HIV-1感染者的env基因V3—V4区,gag基因P17/P24区和tat基因第一外显子区进行扩增，对各基因区阳性扩增样本进行序列测定，并对各基因区核营酸进行序列分析。结果 所有日标人群中共存在B',C2种亚型以及CRF08-BC和CRFO1-AE 2种重组毒株，B'亚型在人群和地域上分布最广，涉及献血员、受血者以及二者的配偶和性乱人群，主要分布既往有偿献血员集中的地区。CRF08-BC,CRF01-AE重组主要涉及性乱人群，分布于经济发达的城市或地理位置偏南方的地区。C亚型为离散病例，主要涉及静脉毒品注射者。结论 湖北省已由既往单一HIV-1 B'亚型转变为多种亚型、重组亚型流行的复杂局面，各亚型在省内高危人群和地域分布不平衡，各有特点，从总的亚型流行特征来着，HIV-1在湖北省有加快流行和进一步复杂化的趋势。 |
| 英文摘要: |
| Objective To study the distribution of human immunodeficiency virus-1 (HIV-1)genotypes in Huhei province.Methods Epidemiological survey was carried out to HIV-1 carriers who were identified in Hubei province.HIV-1 env V3-V4,gag P17/24 and the first exon of tat region were amplified by nested-polymerase chain rwction(nPCR).The sequences were determined,and phylogenetic analyses were then performed.Results 4 HIV-1 strains or circulating recombinant forms (CRFs) were identified in Hubei province with subtype B' the predominant which covered 5 kinds of populations including former blood donors,blood receivers,spouses of the infected people,sex workers and their clients,homosexuals,mainly distributed in the areas with many former blood donors.CRFO8-BC and CRF01-AE were found distributed in economically more developed cities or southern area of the province,and the major transmission routs was through sexual contact.Only 1 patient,an injecting drug user,was identified having subtype C.Conclusion Subtype B' was the main epidemic subtypes in Hubci province while CRF08-BC,CRF01-AE and subtype C were also circulating in the province,indicating the transmission of the disease might to become more complex. |
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