| 刘彦春,李杏红,李兴旺,伦文辉,闫会文,葛蒙梁,朱学骏.690例HIV+/AIDS首诊病例的临床特征及与免疫状态和病毒载量相关性研究[J].中华流行病学杂志,2007,28(10):1026-1029 |
| 690例HIV+/AIDS首诊病例的临床特征及与免疫状态和病毒载量相关性研究 |
| Study on the association of clinical characteristic,CD4+ and level of HIV viral load among 690 initial HIV-infection |
| 收稿日期:2007-05-01 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 艾滋病病毒感染者/艾滋病患者 机会性感染 病毒载量 |
| 英文关键词: Human immunodeficiency virus/Acquired immnunedeficiency syndrom Opportunity infection Viral load |
| 基金项目: |
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| 中文摘要: |
| 目的 以艾滋病病毒(HIV)感染的首诊病例分析临床特征与免疫状态和病毒载量的关系。方法 横断面分析了690例HIV感染病例，采用SPSS l3.0统计软件分析。结果 690例HIV感染病例中男性是女性的2倍，平均年龄35.3岁；感染途径以性途径传播为主，其中用男男性行为和异性性
行为而感染的分则是17.5%和16.7%；男男性行为感染者以来自北京地区且学历在大学以上者为主；夫妻间性传播感染占7.8%，双性性行为感染占11.6%。来自河南、安徽、山西、河北等地区的非法采供血/血浆和接受HIV污染的受血者，在发现感染原因中以氏院的各种筛查为主，尤其足因皮肤病性病的筛
查而发现占多数，发现时多数病例已有严重的免疫缺陷，其中37.3%的病例CD4+T淋巴细胞<50个/μl；此外，婚前和孕期榆查、出人境检疫等都足重要的发现环节；首诊时临床的系统疾病发病率前瓦他依次是：皮肤病、肺炎、上呼吸道感染、肝炎、消化道念珠菌病；此时患者同时合并的病种增加；但当CD4+T淋巴细胞>251个/μl时，各种疾病的发病减少；病毒载最越高，CD4+T淋巴细胞数越低．机会感染和并发症越多。结论 首诊时HIV感染患者的免疫水平已经很低，病情已经接近艾滋病期。 |
| 英文摘要: |
| Objective To understand the correlation between CD4+ cell count,HIV viral load (VL) and clinical characteristics among patients whrn H1V-1 was tested positive and initial AIDS diagnosis was made.Methods 690 HIV-infected cases from Beijing Di-Tan Hospital were included and under a cross sectional study while Sl'SS statistical method was used.Results The 690 HIV-infected cases would include 458 males and 232 females with age range from 2—72 years (mean age as 35.3).The modes of transmission showed that; homosexual contact taking up 17.5% while heterosexual was 16.7%.Most of the homosexual-infected ones lived in Beijing and most of them had bachelor or master's degrees.l9.4% of the transmission happened between heterosexual/bisexual couples,suggesting that HIV was transmitted through the "bridge population" while the rest were infected by contaminated blood/plasma.Many of the cases were identified when they lately visited the pre-operation surveillance point in the hospital.Serious immunodeLiciency symptoms or sighs were discovered as:CD4+ count<50 cell/μl,serious opportunistic infections including pneumocysiosis pulmonary,cerebral toxoplasmasis and cryptocoecal meningitis.Higher frequencies of diseases seen were dermotosis,pneumonia,upper respiratory tract infection,hepatitis and digestive tract moniliasis.Conclusion Because of the late identification of the disease,serious immuo-suppression situation often appeared,suggesting that there was an urgent need to improve STD/AIDS knowledge on those HIV(+)people so they might have an early access to accept medical care. |
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