文章摘要
韩梅,王豫林,王慜杰,周全华,蒋岩.应用BED-CEIA方法估算重庆市静脉吸毒人群艾滋病病毒感染的发病率[J].中华流行病学杂志,2007,28(11):1077-1080
应用BED-CEIA方法估算重庆市静脉吸毒人群艾滋病病毒感染的发病率
Application of BED-CEIA to estimate the human immunodeficiency Virus preVaIence among injecting drugllsers in Chongqing municipality
投稿时间:2007-04-12  
DOI:
中文关键词: 艾滋病病毒;BED一酶联方法;发病率;静脉吸毒人群
英文关键词: Human immunodeficiency virus; BED-capture enzyme immunoassay; Incidence;Iniection drug users
基金项目:中美艾滋病防治合作资金资助项目(5u62PS022883-5)
作者单位E-mail
韩梅 重庆市疾病预防控制中心, 400042  
王豫林 重庆市疾病预防控制中心, 400042  
王慜杰 中国疾病预防控制中心性病艾滋病预防控制中心  
周全华 重庆市疾病预防控制中心, 400042  
蒋岩 中国疾病预防控制中心性病艾滋病预防控制中心 jiangyan03@263.Net 
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中文摘要:
      目的检测重庆市静脉吸毒人群中艾滋病病毒(HIV)新近感染状况并计算HIv发病率。方法收集重庆市两个监测哨点自1999-2006年以来的监测样本共计4711份,通过酶联免疫和蛋白印迹实验检测出HIV一1感染的样本,再应用Ig-G一捕获HIV一1 BED一发病率酶联方法(BED-CEIA),检测其中的新近感染样本,进而估算该人群的HIv.1发病率。结果共检出HIv一1阳性样品130份。哨点A 2001-2005年HIV感染率分别为O.73%、2.02%、1.54%、2.96%、2.80%,发病率分别为O.57%、0.93%、0、1.24%、1.68%;哨点B 2004 2006年HIV感染率分别为4.21%、9.96%、8.13%,发病率分别为O.95%、1.04%、O.90%。虽然两个哨点在发病率方面都有起伏,但差异无统计学意义,感染率与发病率变化趋势一致。结论目前在莺庆市监测哨点发现的HIV感染者大部分为既往感染者,发病率维持在较稳定的范围。
英文摘要:
      objective To estimate the human immunodeficiency virus(HIV一1) prevalence ofinjecting drug users(IDUs)in Chongqing city. methods To apply BED-capture enzyme immunoassay(CEIA) which was based on the principle of HIV-antibody va ries as the disease progress, in order toestimate both the HIV incidence and prevaIence of IDUs from two IDUs surveillance sites in C}10ngqing.results Du“ng the research period,4711 serum samples were tested bv ELISA and 130 were HIV一1positive,confirmed by Western blot.The prevalence of IDUs surveillance site A from 1 999 to 2006 were0.73%,2.02%,1.54%,2.96%and 2.80%,and the incidence rates were O.57%,O.93%,0,1.24%and 1.68% respectivelv. The prevalence of IDUs surveillance site B appeared to be 4.21%,9.96%,8.13%,and the incidence rates were 0.95%,1.04%and 0.90%respectively,from 2004 to 2006.conclusion Many of the IDUs HIV carriers in Chongqing had been infected for long time, and theincidence rates among them were steady,keeping at the same level for 1-2 years. PrOmotion on interventionfor IDUs had produced certain effects but more attention still necds to be paid.
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