文章摘要
王艳,黄久仪,曹奕丰,郭吉平,扬永举,俞学海,沈风英,王桂清.上海市奉贤社区脑卒中危险因素队列研究基线调查和随访分析[J].中华流行病学杂志,2007,28(12):1171-1174
上海市奉贤社区脑卒中危险因素队列研究基线调查和随访分析
Baseline study and analysis on a stroke risk factor-related cohort in Fengxian county of Shanghai
收稿日期:2007-05-10  出版日期:2014-09-12
DOI:
中文关键词: 脑卒中;血液动力学;危险因素;队列研究
英文关键词: Stroke;Hemodynamic;Risk factor;Cohort study
基金项目:上海市科委资助项目
作者单位E-mail
王艳 上海市脑血管病防治研究所, 201318  
黄久仪 上海市脑血管病防治研究所, 201318  
曹奕丰 上海市脑血管病防治研究所, 201318  
郭吉平 上海市脑血管病防治研究所, 201318  
扬永举 上海市脑血管病防治研究所, 201318  
俞学海 上海市脑血管病防治研究所, 201318  
沈风英 上海市脑血管病防治研究所, 201318  
王桂清 上海市脑血管病防治研究所, 201318 webmaster@strokepre.com 
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中文摘要:
      目的了解上海市奉贤社区脑卒中危险因素暴露水平并探讨各危险因素与脑卒中发病间的关系.方法2003与2004年整群抽取上海市奉贤区两个社区≥40岁本市户籍常住人口10 565人建立脑卒中队列研究人群,调查高血压病、心脏病、糖尿病、脑卒中家族史、吸烟、饮酒等危险因素暴露状况,并进行脑血管血液动力学指标(CVHI)检测,以统一方法对CVHI进行积分,积分值<75分为异常,随访脑卒中新发病例共78例,对研究因素进行单因素和多因素Cox回归分析.结果2003年基线调查显示,该社区高血压病、心脏病、糖尿病、脑卒中家族史、肥胖(BMI≥28 kg/m2)、吸烟、饮酒、CVHI积分异常等八项的暴露率分别为21.14%、6.72%、1.88%、5.63%、4.17%、34.96%、17.81%、29.43%.通过2-3年脑卒中病例随访,单因素分析显示,这八项的相对危险度(RR)及其95%CI分别为:高血压病2.76(1.76~4.32)、心脏病2.19(1.16~4.14)、糖尿病1.52(0.38~6.19)、脑卒中家族史1.58(0.69~3.62)、肥胖1.24(0.45~3.38)、吸烟1.75(1.12~2.73)、饮酒2.10(1.30~3.39)、CVHI积分异常12.72(7.02~23.06).多因素Cox回归分析显示,被筛选进入回归方程的因素是吸烟和CVHI积分异常.结论高血压病、心脏病、吸烟、饮酒、CVHI积分异常与脑卒中发病有显著的病因学联系,CVHI积分异常和吸烟是脑卒中独立的预测因子.
英文摘要:
      ObjectiveTo explore the exposed level of stroke risk factors in Fengxian county of Shanghai and the relationships between risk factors and stroke.MethodsCommunity based populations including 10 565 individuals aged 40 years old and over were cluster sampled from Fengxian county in 2003 or 2004.Status of exposure on common risk factors such as hypertension,cardiovascular disease,diabetes, family history of stroke,cigarette smoking,alcohol intake were gathered while cerebral vascular hemodynamic index (CVHI) was examined,with CVHI score below 75 points as abnormal.During 2003 to 2006,78 stroke cases occurred.The relationships between risk factors and stroke were analyzed by univariate and Cox proportional hazards regression models.ResultsRates of exposure regarding hypertension,cardiovascular disease,diabetes,family history of stroke,obesity (BMI≥28 kg/m~2), smoking,drinking and CVHI score abnormal were 21.14%,6.72%,1.88%,5.63%,4.17%, 34.96%,17.81% and 29.43%,respectively.Data from Univariate analysis indicated that relative risk (95 % CI) of above-mentioned risk factors were 2.76(1.76-4.32),2.19(1.16-4.14),1.52(0.38-6.19),1.58(0.69-3.62),1.24(0.45-3.38),1.75(1.12-2.73),2.10(1.30-3.39) and 12.72(7.02-23.06), respectively.Results from Cox proportional hazards regression models analysis showed that cigarette smoking,CVHI score abnormal were screened into equation.ConclusionAmong all the risk factors,rate of hypertension was the highest while hypertension,cardiovascular disease,cigarette smoking,alcohol intake and abnomal CVHI score had remarkable etiological correlations to stroke.Abnormal CVHI score, cigarette smoking seemed to be the independent forecasting factors related to stroke
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