| 龚震宇,翁景清,雷金宝,方春福,陈恩富,王臻,陈忠兵,王炜,何凡,刘碧瑶,林君芬,丁钢强.浙江省肾综合征出血热疫苗接种现场人群免疫后10年效果评估[J].中华流行病学杂志,2007,28(12):1190-1193 |
| 浙江省肾综合征出血热疫苗接种现场人群免疫后10年效果评估 |
| Study on a 10-year protective effects of vaccination against hemorrhagic fever with renal syndrome |
| 收稿日期:2007-07-12 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 肾综合征出血热 疫苗 保护效果 |
| 英文关键词: Hemorrhagic fever with renal syndrome Vaccine Protective effect |
| 基金项目:国家科技攻关项目 |
| 作者 | 单位 | | 龚震宇 | 浙江省疾病预防控制中心, 杭州, 310009 | | 翁景清 | 浙江省疾病预防控制中心, 杭州, 310009 | | 雷金宝 | 龙游县疾病预防控制中心 | | 方春福 | 衢州市疾病预防控制中心 | | 陈恩富 | 浙江省疾病预防控制中心, 杭州, 310009 | | 王臻 | 浙江省疾病预防控制中心, 杭州, 310009 | | 陈忠兵 | 龙游县疾病预防控制中心 | | 王炜 | 衢州市疾病预防控制中心 | | 何凡 | 浙江省疾病预防控制中心, 杭州, 310009 | | 刘碧瑶 | 浙江省疾病预防控制中心, 杭州, 310009 | | 林君芬 | 浙江省疾病预防控制中心, 杭州, 310009 | | 丁钢强 | 浙江省疾病预防控制中心, 杭州, 310009 |
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| 中文摘要: |
| 目的连续观察和评价肾综合征出血热疫苗免疫接种人群10年后的流行病学和血清学效果.方法在浙江省龙游县以村为单位,16～60岁健康者按接种和对照各半的原则随机分组.采用间接免疫荧光法检测特异性IgG荧光抗体,用微量细胞病变中和试验测中和抗体,以抗体滴度评价血清学免疫效果和用疫苗保护率评价防病效果.结果接种前血清抗体阴性者全程接种后2周荧光抗体阳转率为100%(67/67),95%CI:96.3%～100%,中和抗体阳转率为44.4%(8/18),95%CI:22.0%～69.0%,几何平均滴度分别为72.1和4.6.1年后进行加强免疫,加强免疫前、免疫后2周,加强免疫后1、1.5、2、3和5年,荧光抗体阳性率分别为28.6%、83.3%、75.0%、53.1%、22.6%、10.0%、55.0%;中和抗体阳性率分别为14.8%、55.6%、35.0%、31.3%、26.0%、10.0%、50.0%.基础免疫后10年,荧光抗体阳性率下降到7.1%.但是现场流行病学保护效果很好,人群保护率达100%.结论肾综合征出血热疫苗长期免疫效果良好,流行病学防病效果明显,经济和社会效益显著. |
| 英文摘要: |
| ObjectiveTo evaluate the epidemiological and serological efficacy after 10 years of vaccination against hemorrhagic fever with renal syndrome (HFRS) vaccines in Zhejiang province.MethodsOne county was randomly chosen as the research unit with all the healthy people between 16 and 60 years old were equally divided into study and control groups.The study group was vaccinated,Immunofluorescent antibody assay was used to test specific IgG antibody and Mero-CPE method was used to test the titer of neutralizing antibody.ResultsTwo weeks after the full-course immunization,the seroconversion rate became 100 % (67/67,with 95% CI as 96.3%-100%) by immunofluorescent antibody test (IgG) and 44.4 % (8/18 with 95 % CI as 22.0 %-69.0%) by neutralization test with GMT titers as 72.1 and 4.6 respectively.Booster immunization was provided one year later.Time span as two weeks prior to,one year, one and half years,two years,three years and five years after booster immunization,the rates of seroconversion on immunofluorescent antibody using IFAT method,were 28.6%,83.3%,75.0%, 53.1%,22.6%,10.0% and 55.0% respectively,and rates of seroconversion of neutralizing antibody by Mero-CPE method were 14.8%,55.6%,35.0%,31.3%,26.0%,10.0% and 50.0% respectively.Nine years after the reinforcement,the rates of seroeonversion of immunofluorescent antibody by IFAT method was only 7.1%.The vaccinated group had no patient seen but the control group appeared 34 patients including 3 deaths.According to the ten-year observation,the vaccine seemed effective with the protection rate in population reached 100 %.ConclusionHFRS vaccine was effective on epidemiological,social and economical efficacy. |
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