文章摘要
潘洁,宋辉,潘小川.中国职业性汞暴露对女工生殖功能影响的Meta分析[J].中华流行病学杂志,2007,28(12):1215-1218
中国职业性汞暴露对女工生殖功能影响的Meta分析
Reproductive effects of occupational exposure to mercury on female workers in China: a Meta-analysis
收稿日期:2007-06-28  出版日期:2014-09-12
DOI:
中文关键词: 汞;女性;生殖功能;Meta分析
英文关键词: Mercury;Female;Reproductive function; Meta-analysis
基金项目:
作者单位E-mail
潘洁 宁夏医学院公共卫生学院劳动卫生教研室, 银川, 750004  
宋辉 宁夏医学院公共卫生学院劳动卫生教研室, 银川, 750004  
潘小川 北京大学公共卫生学院劳动卫生与环境卫生学系 xcpan@bjmu.edu.cn 
摘要点击次数: 778
全文下载次数: 0
中文摘要:
      目的 综合分析职业性汞暴露对女工生殖功能的影响,筛选汞暴露的敏感生殖效应指标.方法 运用计算机和手工检索收集1989-2006年间国内发表的关于职业性汞暴露与女工生殖功能关系的文献,经严格筛选后,应用Rev Man软件对入选文献的研究结果进行一致性检验并采用相应的数学模型进行数据合并,采用Meta分析合并RR值作为各项目的总效应指标.结果 纳入14篇文献(暴露组2148人,对照组2044人),与对照组比较,职业性汞暴露与女性月经经期(RR=1.82,95% CI:1.45~2.30)、月经周期(RR=2.03,95% CI:1.74~2.37)、月经量的改变(RR=2.06,95% CI:1.47~2.09)、痛经(RR=2.14,95% CI:1.54~2.99)、妊娠高血压(RR=2.17,95% CI:1.32~3.57)、死产死胎(RR=2.54,95% CI:1.41~4.56)及女工子代低体重出生(RR=3.39,95% CI:1.38~8.33)和出生缺陷(RR=2.67,95% CI:1.55~4.60)等的正相关有显著的统计学意义(P<0.05).结论 职业性汞暴露可以引起女工月经经期、周期和经量改变,增加痛经,同时还会影响妊娠及其子代发育,表现为增加妊娠高血压和死产死胎的发生,并导致其子代低体重和发生出生缺陷.
英文摘要:
      ObjectiveTo analyze and evaluate the reproductive effects of occupational exposure to mercury among female workers and to identify relative sensitive indicators.MethodsDocuments on the relations of occupational exposure to mercury and reproductive effects on female workers were collected through computer and manually that were published in Chinese language during 1989 2006.After strict selection,homogeneity test and integrated analysis for the abstracted data of the eligible studies were conducted using Review Manager Statistic Software.Combined RR value was used as the index for total effect on each project for Meta-analysis.ResultsIn total,14 original research papers were included (totally 2148 subjects and 2044 controls).When comparing to the controls,the occupational exposure to mercury was significantly associated with longer menstrual period (RR=1.82,95% CI:1.45-2.30),menstrual cycle delay (RR=2.03,95% CI:1.74-2.37) and the changes of menstrual blood volume (RR=2.06, 95%CI:l.47-2.09),dysmenorrhea (RR 2.14,95%CI:1.54-2.99),pregnancy-induced hypertension (RR=2.17,95 % CI:1.32- 3.57),stillbirths (RR=2.54,95 % CI:1.41-4.56) and low birth weight (RR=3.39,95 % CI:1.38-8.33)/birth defect (RR=2.67,95 % CI:1.55-4.60) of their offspring (P0.05).ConclusionOccupational exposure to mercury could cause dysfunction of the menstrual period, menstrual cycle,menstrual blood volume,as well as dysmenorrhea for female workers being exposed to mercury and inducing adverse reproductive outcomes,including pregnancy-induced hypertension,stillbirth, low birth weight and birth defects of their offspring.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭