文章摘要
俞顺章.流行病学与计算机应用第四讲筛检试验[J].中华流行病学杂志,2008,29(1):88-90
流行病学与计算机应用第四讲筛检试验
Eco-epidemiology: newly discovered infectious diseases; basic concepts
收稿日期:2007-04-26  出版日期:2014-09-18
DOI:
中文关键词: 筛检试验;敏感度;特异度;约登指数
英文关键词: Eco-epidemiology;Emerging disease;Concepts
基金项目:
作者单位
俞顺章 复旦大学预防医学研究所,上海,200032 
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中文摘要:
      筛检试验是开展现况调查和疾病早发现、早诊断、早治疗的基础.要找到一个好的筛检方法需经过严格的统计检验和现场流行病学的试验.本文就筛检试验的方法进行介绍。
英文摘要:
      Objective Recently studies showed infections of Chlamydia pneumoniae (Cp), Helicobacter pylori (Hp) and cytomegalovirus (CMV) played roles in the development of atherosclerosis. The aim of this study was to study relationship between infection of Cp, Hp and CMV, systemic inflammatiom and coronary artery disease (CAD).Methods Fourty-five patients with at least one coronary artery stenosis 50% and 33 control subjects with negative coronary angiography were recuited for this case-control study from May 2000 to October 2001. Antibodies against Cp, Hp and CMV were measured and serum C-reactive protein (CRP) levels determined for each case. CRP level 0.8 mg/dl was defined at elevated CRP level.Results The prevalence of Cp IgG, Hp IgG or Hp IgA antibody was associated with CAD (P=0.017, P 0.001, P=0.009). After adjustment for age, gender, smoking, hypertension, hyperlipidemia and diabetes, the association was still seen. Mean CRP value was significantly higher in patients with CAD, compared to those without CAD (P 0.001). Multivariate analysis showed statistical significance (P=0.03). Elevated levels of CRP were found to be an important parameter for CAD (P=0.032). The prevalence of Cp IgG antibody, Hp IgG and CMV IgG antibody all showed no association with elevated levels of CRP (P=0.391, P=0.253, P=0.724). The ratio of elevated levels of serum basic CRP in the group with IgG antibodies to 3 pathogens was 32.1% while in the group with IgG antibodies to ≤2 pathogens it was 14.9%. But with no significante difference between the two (P=0.078).Conclusions Two chronic infections, Cp and Hp, might increase the risk of CAD. There was no association of CMV infection with CAD. C-reactive protein was an independent parameter of CAD, but the increased systemic inflammation in CAD did not seem to be related to aforesaid infection.
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