饮绿茶与成年人白血病发病风险的病例对照研究

张宣东; 赵小英; 张敏; 梁赟; 许晓华; C.D'ArcyJ.Holman

文章摘要

张宣东,赵小英,张敏,梁赟,许晓华,C.D'ArcyJ.Holman.饮绿茶与成年人白血病发病风险的病例对照研究[J].中华流行病学杂志,2008,29(3):290-293

饮绿茶与成年人白血病发病风险的病例对照研究

A case-control study on green tea consumption and the risk of adult leukemia

收稿日期:2007-09-17 出版日期:2014-09-15

DOI：

中文关键词: 白血病病例对照研究绿茶

英文关键词: Leukemia Case-control study Green tea

基金项目:

作者	单位	E-mail
张宣东	浙江大学医学院附属第二医院 310009 杭州
赵小英	浙江大学医学院附属第二医院 310009 杭州	zhaoxy0731@yahoo.com.cn
张敏	The School of Population Health, The University of Western Australia, Perth, WA, Australia
梁赟	浙江大学医学院附属第二医院 310009 杭州
许晓华	浙江大学医学院附属第二医院 310009 杭州
C.D'ArcyJ.Holman	The School of Population Health, The University of Western Australia, Perth, WA, Australia

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中文摘要:

目的探讨饮用绿茶与成年人白血病发病风险的关系.方法采用配对病例对照研究,收集2005年1月至2006年12月确诊的白血病患者107例,以同期骨科非肿瘤住院患者110例对照,采用面对面交谈的方式,使用统一的调查问卷,收集所有对象的饮茶量、饮茶持续年限和频率、暴露于放射线及职业危害因素、药物应用等信息;用SPSS软件进行单因素、多因素非条件logistic回归分析评估OR值及其95%CI,.结果与不饮茶组相比,随着饮用绿茶的量、持续年限和频率增加,成年人患白血病的危险度呈下降趋势.单因素分析显示,饮绿茶组患白血病的OR=0.58(95%CI:0.34～1.00;P＜0.05),在对性别、年龄、居住地、吸烟、受教育程度、暴露于射线及职业危害因素等混杂因素进行调整后,饮绿茶组发生白血病的OR=0.52(95%CI:0.28～0.98;P=0.04),且随着饮茶频率、饮茶年限和饮用茶叶量的增加,OR值逐渐降低,结果有统计学意义.结论 饮绿茶可能是成年人白血病的保护性因素,并与饮绿茶频率、饮绿茶量及饮绿茶时间有关.

英文摘要:

Objective To investigate whether green tea consumption can reduce the risk of adult leukemia. Methods A hospital-based matched case-control study was conducted in 2005一2006. We recruited 107 confirmed leukemia cases and 110 inpatient controls with orthopedic disease without leukemia or other malignancy matched on gender, age and hospitals that patients stayed. Related information were gathered on quantity, duration and frequency of tea consumption, demographic characteristics, exposure to radiation and occupational hazards, medications, using a validated questionnaire by face-to-face interview. Univariate and multivariate unconditional logistic regression analysis were used to estimate odds ratios (ORs) and associated 95% confidence intervals(Cls) with SPSS 11.5 software. Results Compared with non-tea-drinkers, the OR of those who consumed green tea was 0. 58 ( 95 % CI:0.34-1.00，P< 0.05) under univariate statistical analysis. The OR was 0. 52 ( 95 96 CI:0.28-0.98, P=0.04)，using logistic regression to count for age, gender, residential area, smoking, level of education, exposure to radiation, benzene and organo-phosphorus. Compared with non-drinkers, the risk of adult leukemia declined with increasing quantity,duration,and frequency of green tea consumption. Tests for trend on dose-response was statistically significant (P<0.01)Conclusion A higher consumption of green tea seemed to be associated with a declined risk of adult leukemia. Tea consumption might be of help to human health planning projects.

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