大气可吸入颗粒物与心脑血管疾病急诊关系的病例交叉研究

郭玉明; 刘利群; 陈建民; 杨敏娟; Wichmann; 潘小川

文章摘要

郭玉明,刘利群,陈建民,杨敏娟,Wichmann,潘小川.大气可吸入颗粒物与心脑血管疾病急诊关系的病例交叉研究[J].中华流行病学杂志,2008,29(11):1064-1066

大气可吸入颗粒物与心脑血管疾病急诊关系的病例交叉研究

Association between the concentration of particulate matters and the hospital emergency room visits for circulatory diseases: a case-crossover study

收稿日期:2008-07-03 出版日期:2014-09-11

DOI：

中文关键词: 心脑血管疾病可吸入颗粒物病例交叉研究

英文关键词: Circulatory diseases Particulate matter Case-crossover study

基金项目:国家自然科学基金重点资助项目(20637026)

作者	单位	E-mail
郭玉明	北京大学医学部公共卫生学院劳动卫生与环境卫生学系, 100191	xcpan@bjmu.edu.cn
刘利群	北京大学医学部公共卫生学院劳动卫生与环境卫生学系, 100191
陈建民	北京大学第三医院病案室
杨敏娟	北京大学医学部公共卫生学院劳动卫生与环境卫生学系, 100191
Wichmann	GSF-National Research Centre for Environment and Health, Munich German
潘小川	北京大学医学部公共卫生学院劳动卫生与环境卫生学系, 100191

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中文摘要:

目的探讨北京市大气可吸入颗粒物污染(PM₁₀)对心腩血管疾病急诊的影响.方法收集北京大学第三医院急诊科心脑血管疾病急诊资料和北京市环境监测中心大气污染物数据,应用时间分层的病例交叉设计研究方法进行数据分析.结果无滞后单向同顾性1:4配对病例交叉研究的效应值(OR值)最大,在控制所选PM₁₀当日气温、相对湿度影响的情况下,PM₁₀浓度每提高10μg/m³与心脑血管疾病急诊(ICD-10:I00-I99)、冠心病急诊(ICD-10:120-125)、心律失常急诊(ICD-10:147-149)、心衰急诊(ICD-10:150)和脑血管疾病急诊(ICD-10:160-169)的OR值分别为1.006(95%CI:1.003～1.008)、1.003(95%CI:0.996～1.010)、1.005(95%CI:0.997～1.013)、1.019(95%CI:1.005～1.033)、1.003(95%CI:0.998～1.007),其中PM₁₀与总心脑血管疾病急诊和心衰急诊的关联有统计学意义(P<0.05).结论大气PM₁₀污染物浓度升高可导致总心脑血管疾病急诊和心衰急诊增加.

英文摘要:

Objective To explore the association between the concentration of particulate matters with an aerodynamic diameter of <10 μm ( PM10 ) and the hospital emergency room visits for circulatory diseases ( International Classification of Diseases, tenth vision ICD-10 : 100-199) in Beijing, China. Methods We collected data for daily hospital emergency room visits of circulatory diseases ( ICD-10:I00-I99 ) from Peking University Third Hospital and from the ambient air PM₁₀ through the Beijing Municipal Environmental Monitoring Center. A time-stratified case-crossover design was used to evaluate associations between circulatory disease health outcomes and PM₁₀.Results The no-lagged unidirectional case-crossover design with 1:4 matched pairs had the highest odds ratios (ORs) between PM₁₀ and the hospital emergency room visits for circulatory diseases. After adjusting the temperature and the relative humidity, a 10μg/m³ increased in the PM₁₀ were found associated with the emergency room visits on value of ORs of 1.006(95% CI:1.003-1.008) for the total circulatory diseases ( ICD-10:I00-I99), 1.003 (95% CI:0.996-1.010) for coronary heart disease ( ICD-10:I20-I25 ), 1.005 ( 95 % CI:0.997-1.013 ) for cardiac arrhythmia ( ICE)-10:I47-I49), 1.019 (95 % CI:1.005-1.033 ) for heart failure disease ( ICD-10:I50 ),and 1.003 ( 95 % CI : 0.998-1.007 ) for cerebrovascular diseases ( ICD-10:I60-I69 ), respectively. Conclusion These findings suggested that elevated levels of ambient PM₁₀ were positively associated with hospital emergency room visits for the total number of circulatory diseases and heart failure disease.

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